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      ERBB receptors and cancer: the complexity of targeted inhibitors.

      1 ,
      Nature reviews. Cancer
      Springer Science and Business Media LLC

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          Abstract

          ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the expression or activation of epidermal growth factor receptor and ERBB2 are altered in many epithelial tumours, and clinical studies indicate that they have important roles in tumour aetiology and progression. Accordingly, these receptors have been intensely studied to understand their importance in cancer biology and as therapeutic targets, and many ERBB inhibitors are now used in the clinic. We will discuss the significance of these receptors as clinical targets, in particular the molecular mechanisms underlying response.

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          Author and article information

          Journal
          Nat Rev Cancer
          Nature reviews. Cancer
          Springer Science and Business Media LLC
          1474-175X
          1474-175X
          May 2005
          : 5
          : 5
          Affiliations
          [1 ] Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland. Hynes@fmi.ch
          Article
          nrc1609
          10.1038/nrc1609
          15864276
          9ad2d9fa-7adb-476b-a255-657fc1f163b2
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