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      ERBB receptors and cancer: the complexity of targeted inhibitors.

      Nature reviews. Cancer

      drug effects, Signal Transduction, physiology, immunology, antagonists & inhibitors, Receptor, ErbB-2, Receptor Protein-Tyrosine Kinases, etiology, drug therapy, Neoplasms, Humans, Drug Resistance, Neoplasm, Drug Delivery Systems, therapeutic use, Antineoplastic Combined Chemotherapy Protocols, Antineoplastic Agents, Antibodies, Monoclonal, Animals

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          Abstract

          ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the expression or activation of epidermal growth factor receptor and ERBB2 are altered in many epithelial tumours, and clinical studies indicate that they have important roles in tumour aetiology and progression. Accordingly, these receptors have been intensely studied to understand their importance in cancer biology and as therapeutic targets, and many ERBB inhibitors are now used in the clinic. We will discuss the significance of these receptors as clinical targets, in particular the molecular mechanisms underlying response.

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          Journal
          10.1038/nrc1609
          15864276

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