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      Preserved clot formation detected by the Thrombodynamics analyzer in patients with cirrhosis.

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          Abstract

          Patients with cirrhosis have substantial alterations in their hemostatic system, which are paradoxically associated with the risk of both bleeding and thrombotic complications. However, it still remains difficult to predict those risks, because results from conventional coagulation tests, such as the prothrombin time (PT) and activated partial thromboplastin time (APTT), do not reflect the complex hemostatic changes in these patients. More sophisticated global hemostasis tests, such as thrombin generation assays, are not standardized for routine use yet. Here we examined the spatial clot growth in plasma from patients with cirrhosis using the novel Thrombodynamics assay, which uses a fundamentally new approach to test plasma hemostatic capacity.

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          Author and article information

          Journal
          Thromb. Res.
          Thrombosis research
          Elsevier BV
          1879-2472
          0049-3848
          May 2015
          : 135
          : 5
          Affiliations
          [1 ] Surgical Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address: j.b.w.potze@umcg.nl.
          [2 ] Surgical Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
          [3 ] Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
          [4 ] Surgical Research Laboratory, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Section of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
          Article
          S0049-3848(15)00097-3
          10.1016/j.thromres.2015.02.025
          25746364
          9ad3105f-0862-4a2f-95a2-7fa481d29f47
          History

          Cirrhosis,Thrombosis,Thrombin generation,Thrombodynamics,Coagulation

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