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      Immunocytochemical Localization of Basic Fibroblast Growth Factor in the Human Pituitary Gland

      ,

      Neuroendocrinology

      S. Karger AG

      Somatotropes, Growth factors, Immunocytochemistry, Pituitary gland, human

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          Abstract

          The immunocytochemical localization of basic fibroblast growth factor (bFGF) was studied in the human pituitary gland using a polyclonal antibody against fraction 1-24 of bovine recombinant bFGF. From a technical perspective, methacarn-fixed tissues were associated with a better preservation of bFGF immunoreactivity. Basic FGF-immunopositive glandular secretory cells were detected from the fetal period to adulthood in the pars distalis. No bFGF-positive cells were found in the neural lobe, basophil invasion areas, pars tuberalis or the walls of the pituitary cleft in the fetal pituitaries where this area was available. Endothelial cells and the axons of the neurohypophysis appeared weakly immunopositive or immunonegative depending on the fixative. According to their morphology, distribution, and the serial section analysis with all the pituitary hormones and vimentin, a folliculostellate cell marker, we conclude that bFGF-positive cells appear to be somatotropes. These results are consistent with the interpretation that bFGF plays a paracrine role in the modulation of the synthesis and secretion of various pituitary hormones.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1995
          1995
          09 April 2008
          : 62
          : 5
          : 523-529
          Affiliations
          Department of Histology and Cell Biology, Faculty of Medicine, University Complutense, Madrid, Spain
          Article
          127043 Neuroendocrinology 1995;62:523–529
          10.1159/000127043
          8559284
          © 1995 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Regulation of Pituitary Cells

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