Visual outcome after posterior uveal melanoma episcleral brachytherapy including radiobiological doses

Abstract

Purpose

To assess the long-term influence of radiobiological doses in the evolution of visual acuity (VA) in patients with uveal melanoma treated by episcleral brachytherapy.

Material and methods

Visual acuity was evaluated prospectively from a case series of 243 patients in 2016 treated with ¹²⁵I. Data analysis was applied to trend VA outcome and find the accurate best-fit line. Biologically effective dose (BED) was included in survival analysis with the use of Kaplan-Meier and Cox regressions. Hazard ratio (HR) and confidence interval at 95% (CI) were determined. Variables statistically significant were analyzed and compared by log-rank tests.

Results

The median follow-up was 74.2 months (range, 3-223). Exponential regression shows a 25% reduction and 50% in visual acuity score (VAS) scale for 5 and 27.8 months, respectively. Cumulative probabilities of survival analysis were 57%, 42%, 27%, and 23% at 3, 5, 10, and 15 years, respectively. Multivariable analysis found tumor height (HR = 1.18, 95% CI: 1.07-1.29), applicator size (HR = 1.22, 95% CI: 1.08-1.36), juxtapapillary localization (HR = 1.70, 95% CI: 1.01-2.84), and dose to foveola (HR = 1.01, 95% CI: 1.00-1.01) significantly associated with VA loss. Log-rank tests were significant for all those variables. BED has a strong influence in univariate model, but not statistically significant in the multivariate one.

Conclusions

Visual acuity changes can be modeled by an exponential function for the first 5 years after treatment. No relation between VA loss and BED has been found; nevertheless, apical height, plaque size, juxtapapillary localization, and dose to fovea were found as statistical significant variables.

Journal

Journal ID (nlm-ta): J Contemp Brachytherapy

Journal ID (iso-abbrev): J Contemp Brachytherapy

Journal ID (publisher-id): JCB

Title: Journal of Contemporary Brachytherapy

Publisher: Termedia Publishing House

ISSN (Print): 1689-832X

ISSN (Electronic): 2081-2841

Publication date (Electronic): 30 April 2018

Publication date (Print): April 2018

Volume: 10

Issue: 2

Pages: 123-131

Affiliations

[1 ]Intraocular Tumors Unit Valladolid University Hospital, Valladolid

[2 ]University of Valladolid, Valladolid, Spain

Author notes

Address for correspondence: David Miguel, MPhys, Hospital Clinico Universitario de Valladolid, C/Avda. Ramón y Cajal s/n, 47003, Valladolid, 47003 Valladolid, Spain. phone: [phone]. e-mail: david.miguel@ 123456outlook.com

Article

Publisher ID: 32735

DOI: 10.5114/jcb.2018.75597

PMC ID: 5961527

Copyright statement: Copyright: © 2018 Termedia Sp. z o. o.

License:

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

Categories

Subject: Original Paper