GenderMedDB: an interactive database of sex and gender-specific medical literature

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Abstract

Background

Searches for sex and gender-specific publications are complicated by the absence of a specific algorithm within search engines and by the lack of adequate archives to collect the retrieved results. We previously addressed this issue by initiating the first systematic archive of medical literature containing sex and/or gender-specific analyses. This initial collection has now been greatly enlarged and re-organized as a free user-friendly database with multiple functions: GenderMedDB ( http://gendermeddb.charite.de).

Description

GenderMedDB retrieves the included publications from the PubMed database. Manuscripts containing sex and/or gender-specific analysis are continuously screened and the relevant findings organized systematically into disciplines and diseases. Publications are furthermore classified by research type, subject and participant numbers. More than 11,000 abstracts are currently included in the database, after screening more than 40,000 publications. The main functions of the database include searches by publication data or content analysis based on pre-defined classifications. In addition, registrants are enabled to upload relevant publications, access descriptive publication statistics and interact in an open user forum.

Conclusions

Overall, GenderMedDB offers the advantages of a discipline-specific search engine as well as the functions of a participative tool for the gender medicine community.

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Most cited references 11

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Association of age and sex with myocardial infarction symptom presentation and in-hospital mortality.

John Canto, William J Rogers, Robert J. Goldberg … (2012)

Women are generally older than men at hospitalization for myocardial infarction (MI) and also present less frequently with chest pain/discomfort. However, few studies have taken age into account when examining sex differences in clinical presentation and mortality. To examine the relationship between sex and symptom presentation and between sex, symptom presentation, and hospital mortality, before and after accounting for age in patients hospitalized with MI. Observational study from the National Registry of Myocardial Infarction, 1994-2006, of 1,143,513 registry patients (481,581 women and 661,932 men). We examined predictors of MI presentation without chest pain and the relationship between age, sex, and hospital mortality. The proportion of MI patients who presented without chest pain was significantly higher for women than men (42.0% [95% CI, 41.8%-42.1%] vs 30.7% [95% CI, 30.6%-30.8%]; P < .001). There was a significant interaction between age and sex with chest pain at presentation, with a larger sex difference in younger than older patients, which became attenuated with advancing age. Multivariable adjusted age-specific odds ratios (ORs) for lack of chest pain for women (referent, men) were younger than 45 years, 1.30 (95% CI, 1.23-1.36); 45 to 54 years, 1.26 (95% CI, 1.22-1.30); 55 to 64 years, 1.24 (95% CI, 1.21-1.27); 65 to 74 years, 1.13 (95% CI, 1.11-1.15); and 75 years or older, 1.03 (95% CI, 1.02-1.04). Two-way interaction (sex and age) on MI presentation without chest pain was significant (P < .001). The in-hospital mortality rate was 14.6% for women and 10.3% for men. Younger women presenting without chest pain had greater hospital mortality than younger men without chest pain, and these sex differences decreased or even reversed with advancing age, with adjusted OR for age younger than 45 years, 1.18 (95% CI, 1.00-1.39); 45 to 54 years, 1.13 (95% CI, 1.02-1.26); 55 to 64 years, 1.02 (95% CI, 0.96-1.09); 65 to 74 years, 0.91 (95% CI, 0.88-0.95); and 75 years or older, 0.81 (95% CI, 0.79-0.83). The 3-way interaction (sex, age, and chest pain) on mortality was significant (P < .001). In this registry of patients hospitalized with MI, women were more likely than men to present without chest pain and had higher mortality than men within the same age group, but sex differences in clinical presentation without chest pain and in mortality were attenuated with increasing age.

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Therapeutic implications of the gender-specific aspects of cardiovascular disease.

Vera Regitz-Zagrosek (2006)

The manifestations of cardiovascular diseases differ between men and women, as do outcomes after therapeutic interventions. It is important that those involved in drug discovery and development, as well as disease treatment, are aware of these differences because such variations are likely to have an increasing role in therapeutic decisions in the future. Here, I review gender differences in the most frequent cardiovascular diseases and their underlying sex-dependent molecular pathophysiology, and discuss gender-specific effects of current cardiovascular drugs and the implications for novel strategies for drug development.

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Gender matters: an integrated model for understanding men's and women's health.

R. Rieker, Nigel C. Bird (1999)

Health research has failed to adequately explore the combination of social and biological sources of differences in men's and women's health. Consequently, scientific explanations often proceed from reductionist assumptions that differences are either purely biological or purely social. Such assumptions and the models that are built on them have consequences for research, health care and policy. Although biological factors such as genetics, prenatal hormone exposure and natural hormonal exposure as adults may contribute to differences in men's and women's health, a wide range of social processes can create, maintain or exacerbate underlying biological health differences. Researchers, clinicians and policy makers would understand and address both sex-specific and non-sex-specific health problems differently if the social as well as biological sources of differences in men's and women's health were better understood.

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Author and article information

Contributors

Sabine Oertelt-Prigione

Björn-Oliver Gohlke

Mathias Dunkel

Robert Preissner

Vera Regitz-Zagrosek

Journal

Journal ID (nlm-ta): Biol Sex Differ

Journal ID (iso-abbrev): Biol Sex Differ

Title: Biology of Sex Differences

Publisher: BioMed Central

ISSN (Electronic): 2042-6410

Publication date Collection: 2014

Publication date (Electronic): 23 May 2014

Volume: 5

Page: 7

Affiliations

[1 ]Institute of Gender in Medicine, Charité-Universitätsmedizin Berlin, Hessische Str. 3/4, Berlin 10117, Germany

[2 ]German Center for Cardiovascular Research (DZHK), Berlin, Germany

[3 ]Structural Bioinformatics Group, Charité-Universitätsmedizin Berlin, Berlin 13125, Germany

[4 ]German Cancer Consortium (DKTK), Heidelberg 69120, Germany

[5 ]Center for Cardiovascular Research (CCR), Charité-Universitätsmedizin Berlin, Berlin 10115, Germany

Article

Publisher ID: 2042-6410-5-7

DOI: 10.1186/2042-6410-5-7

PMC ID: 4047004

PubMed ID: 24904731

SO-VID: 9adfe53a-c8ae-4811-b2ec-692824740c0e

License:

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

History

Date received : 20 March 2014

Date accepted : 9 May 2014

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GenderMedDB: an interactive database of sex and gender-specific medical literature

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Abstract

Background

Description

Conclusions

Related collections

Sex and gender-sensitive medicine

Most cited references 11

Association of age and sex with myocardial infarction symptom presentation and in-hospital mortality.

Therapeutic implications of the gender-specific aspects of cardiovascular disease.

Gender matters: an integrated model for understanding men's and women's health.

Author and article information

Contributors

Journal

Affiliations

Article

History

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Cited by 10