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      Quality evaluation of IVM embryo and imprinting genes of IVM babies

      review-article
      Author(s): , ,
      Publication date (Electronic):
      Journal: Journal of Assisted Reproduction and Genetics
      Publisher: Springer US
      Keywords: IVM, Oocytes, Embryo, Oxygen, Epigenetics

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          Abstract

          Purpose

          Oxygen consumption rates of human embryos derived from in vitro matured (IVM) oocytes and controlled ovarian hyperstimulation (COH) were compared with scanning electrochemical microscopy (SECM) non-invasively in order to answer why embryos from IVM oocytes have lower developmental potential. We also analyzed the epigenetic disorders for IVM babies born in our clinic.

          Methods

          The oxygen consumption rate was calculated with the SECM system for different maturation stages of human oocytes, IVM and COH embryos. Blood from umbilical cords of IVM babies was collected to examine the imprinting genes.

          Results

          There were no significant differences in oxygen consumption of embryos at each cleavage stage between IVM and COH (range 0.26–0.56 × 10 14/mol S −1). There also was no abnormality found in expression of imprinting genes in IVM babies.

          Conclusions

          There are no differences in terms of oxygen consumption between embryos derived from IVM and COH. There was no imprinting gene disorder founded from IVM babies.

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          Most cited references18

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          Imprinting disorders and assisted reproductive technology.

          James Segars, Somjate Manipalviratn, Alan DeCherney (2009)
          To review currently available literature on the association between imprinting disorders (Beckwith-Wiedemann syndrome [BWS], Angelman syndrome [AS] and retinoblastoma) and assisted reproductive technology (ART) in humans. Publications related to imprinting/epigenetic disorders including BWS, AS, and retinoblastoma with ART, as well as articles publishing outcome of ART, including IVF and ICSI from July 1978 to February 2008, were identified using PubMed, Medline, and EMBASE. Considerable evidence in animal studies has demonstrated alteration in gene imprinting of embryos cultured in vitro. Publications from Europe, the United States, and Australia have suggested an association between ART and BWS. Importantly, more than 90% of children with BWS that were born after ART had imprinting defects, compared with 40%-50% of children with BWS and conceived without ART. Moreover, there have been other reports suggesting an association between AS and ART. The majority of children with AS born after ART had an imprinting defect as the underlying etiology, specifically loss of methylation of the maternal allele. There was a single report suggesting an increased incidence of retinoblastoma in children conceived with ART. Because the absolute incidence of imprinting disorders is small (<1:12,000 births), routine screening for imprinting disorders in children conceived by ART is not recommended. Additional large cohort studies of children born after ART are needed to determine whether there is a genuine association between ART and imprinting disorders.
          Article 0 comments Cited 49 times – based on 0 reviews     Review now
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            Maturation in vitro of immature human oocytes for clinical use.

            K Y Cha, R.-C. Chian (2015)
            Human oocyte maturation is considered as the reinitiation and completion of the first meiotic division from the germinal vesicle stage (prophase I) to metaphase II, and the accompanying cytoplasmic maturation for fertilization and early embryonic development. Immature human oocytes obtained from patients undergoing gynaecological surgery, or ovulation induction or having polycystic ovary syndrome (PCOS) can be matured and fertilized in vitro. To date, 80% of immature oocytes matured to metaphase II when cultured in maturation medium supplemented with gonadotrophins and 85% of matured oocytes fertilized and cleaved in vitro. Following transfer of these embryos, pregnancies and live births have been achieved. However, the capacity for oocyte maturation was different when the immature oocytes were retrieved from PCOS patients and when the oocytes were cryopreserved at germinal vesicle stage.
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              Oocyte assessment and biological performance.

              Lucinda Veeck (1987)
              Article 0 comments Cited 26 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                : hiroaki@yoshida-lc.jp
                Journal
                Journal ID (nlm-ta): J Assist Reprod Genet
                Journal ID (iso-abbrev): J. Assist. Reprod. Genet
                Title: Journal of Assisted Reproduction and Genetics
                Publisher: Springer US (Boston )
                ISSN (Print): 1058-0468
                ISSN (Electronic): 1573-7330
                Publication date (Electronic): 2 February 2013
                Publication date PMC-release: 2 February 2013
                Publication date (Print): February 2013
                Volume: 30
                Issue: 2
                Pages: 221-225
                Affiliations
                [ ]Yoshida Ladies Clinic, Center for Reproductive Medicine, Sendai, Japan
                [ ]Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University, Yamagata, Japan
                [ ]Environment and Genome Research Center, Tohoku University School of Medicine, Sendai, Japan
                Article
                Publisher ID: 9945
                DOI: 10.1007/s10815-013-9945-9
                PMC ID: 3585685
                PubMed ID: 23378104
                SO-VID: 9af44d48-e6fa-4286-8125-c914321bd9f1
                Copyright © © The Author(s) 2013
                License:

                Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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                Subject: Article
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                issue-copyright-statement © Springer Science+Business Media New York 2013

                ScienceOpen disciplines: Genetics
                Keywords: ivm,oocytes,embryo,oxygen,epigenetics
                Data availability:
                ScienceOpen disciplines: Genetics
                Keywords: ivm, oocytes, embryo, oxygen, epigenetics

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