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      Connexin37 reduces smooth muscle cell proliferation and intimal hyperplasia in a mouse model of carotid artery ligation.

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          Abstract

          Intimal hyperplasia (IH) is an abnormal response to vessel injury characterized by the dedifferentiation, migration, and proliferation of quiescent vascular smooth muscle cells (VSMC) to form a neointima layer. Vascular connexins (Cx) are involved in the pathophysiology of various vascular diseases, and Cx43, the main Cx expressed in VSMC, has been shown to promote VSMC proliferation and IH. The aim of this study was to investigate the participation of another Cx, namely Cx37, in the formation of the neointima layer.

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          Author and article information

          Journal
          Cardiovasc. Res.
          Cardiovascular research
          Oxford University Press (OUP)
          1755-3245
          0008-6363
          Jun 01 2017
          : 113
          : 7
          Affiliations
          [1 ] Department of Vascular Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
          [2 ] Department of Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Laboratory of Experimental Medicine, c/o Department of Physiology, Bugnon 7a, 1005 Lausanne, Switzerland.
          Article
          3755432
          10.1093/cvr/cvx079
          28449099
          9af679ca-c62e-41fd-b2e9-a6b77ad26267
          History

          Carotid artery ligation,Cx37,Cx43,Gap junctions ,Intimal hyperplasia,Proliferation,Smooth muscle cells, Connexin 

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