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      Long-Term Intramuscular Administration of Thyrotropin-Releasing Hormone Tartrate in Patients with Cerebrovascular Disease: Effects on the Pituitary-Thyroid Axis

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          We studied the effects of long-term (30 days) refracted daily intramuscular administration of 4 mg TRH tartrate (TRH-T) on the pituitary-thyroid axis in 20 euthyroid patients affected by cerebrovascular disease (CVD). All subjects were assayed for T<sub>4</sub>, T<sub>3</sub>, FT<sub>4</sub>, FT<sub>3</sub>, TSH and TBG plasma levels before treatment (D<sub>o</sub>), after 15 and 30 treatment days (D<sub>15</sub>, D<sub>30</sub>), and after a 15-day washout (D<sub>45</sub>). In addition, TSH response to 200 µg intravenous TRH was assessed at D<sub>o</sub>, D<sub>30</sub> and D45. We observed a significant increase in T<sub>4</sub>, FT<sub>4</sub> and FT3 levels in the face of decreased TSH concentrations. A blunted TSH response to TRH bolus persisted at D<sub>30</sub>. These data demonstrate that the down-regulation mechanism may be partially overcome in vivo when thyrotrophs are chronically exposed to pharmacological TRH-T doses and that TSH pattern is mainly due to the negative feedback of thyroid hormones, even though pituitary TSH reserves may become depleted. Furthermore, prolonged TRH-T administration does not produce hyperthyroidism in euthyroid CVD patients.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 35
          : 3-4
          : 146-150
          aClinica Medica II and bClinica Medica I, Università di Pisa, Italia
          181891 Horm Res 1991;35:146–150
          © 1991 S. Karger AG, Basel

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          Pages: 5
          Original Paper


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