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      Bioactive molecules of probiotic bacteria and their mechanism of action: a review

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          Abstract

          The bacteria residing in the gut environment do play a pivotal role in metabolic activities of the host. The metabolites produced by these bacteria affect the physiology and health of the host. The gut bacteria are exposed to environmental conditions where multiple factors such as lifestyle, stress, antibiotics, host genetics and infections have an influence on them. In case of pathogenesis of a disease, the gut bacterial composition is altered which leads to a diseased state. This stage is due to colonization of bacterial pathogens in the gut environment. The pathological condition can be alleviated by administering probiotic strains into the gut environment. The probiotic strains produce therapeutic molecules such as amino acids, vitamins, bacteriocins, enzymes, immunomodulatory compounds and short-chain fatty acids. This review discusses recent evidences of the impact of bioactive molecules produced by probiotic bacteria and their mechanism of action in the gut environment to maintain homeostasis and health of the host without any effect on beneficial bacteria sharing the same niche. In addition, the manufacturing challenges of probiotic products for various applications are discussed here.

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          Author and article information

          Contributors
          venki_biotech327@yahoo.com
          krupanidhijuly2012@gmail.com
          Journal
          3 Biotech
          3 Biotech
          3 Biotech
          Springer International Publishing (Cham )
          2190-572X
          2190-5738
          24 July 2019
          August 2019
          : 9
          : 8
          Affiliations
          Department of Bio-Technology, Vignan’s Foundation for Science, Technology and Research, Vadlamudi, Andhra Pradesh 522213 India
          Article
          PMC6656846 PMC6656846 6656846 1841
          10.1007/s13205-019-1841-2
          6656846
          31355115
          9b268b22-3108-409c-9ed5-f41d7c337098
          © King Abdulaziz City for Science and Technology 2019
          Categories
          Review Article
          Custom metadata
          © King Abdulaziz City for Science and Technology 2019

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