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Abstract
A hydrolyzable crosslinker (N,O-dimethacryloylhydroxylamine (MANHOMA)) was synthesized
by a modified method and was characterized using 1H-NMR, FTIR, and melting point determination.
Naltrexone-loaded nanoparticles were prepared by copolymerization of poly(ethylene
glycol)1000 monomethyl ether mono methacrylate (PEO-MA), methyl methacrylate (MMA)
and N,O-dimethacryloylhydroxylamine (MANHOMA) in 0.4% poly(vinyl alcohol) aqueous
solution. The nanoparticles were characterized by FTIR, particle size determination
and transmission electron microscope (TEM). The TEM photomicrographs of the nanoparticles
show a crosslinked core surrounded by a ring formed by the polyethylene glycol tail
of PEO-MA. The loading efficiency of the nanoparticles and in vitro drug availability
from the nanoparticles were investigated. The naltrexone-loaded hydrolyzable crosslinked
nanoparticles were able to sustain the release of naltrexone for different periods
of time, depending on the monomer feed composition.