Cardiac Troponin T Levels at 96 Hours Reflect Myocardial Infarct Size: A Pathoanatomical Study

Abstract

We determined the utility of single-point measurements of circulating cardiac troponin T (cTnT) for the noninvasive estimation of infarct size in 16 beagle dogs after left anterior descending artery (LAD) ligation. Pathoanatomical infarct sizes were determined by the triphenyltetrazolium chloride method and correlated with serum concentration changes of cTnT. Peak cTnT levels (14.10 ± 4.71 μg/l) were reached after 110 ± 21 h. A significant correlation was found between peak cTnT levels (p = 0.0001, r = 0.83) or cumulative cTnT levels and relative infarct size (p = 0.0010, r = 0.72). A single cTnT measurement 96 h after LAD ligation was equally predictive of infarct size (p = 0.0010, r = 0.74) as peak or cumulative cTnT levels derived from serial sampling. cTnT levels at 96 h may thus be useful for practical and cost-effective estimation of infarct size.

Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 2000

Publication date (Print): September 2000

Publication date (Electronic): 02 October 2000

Volume: 93

Issue: 4

Pages: 249-253

Affiliations

^aMedizinische Klinik II, Medizinische Universität zu Lübeck, Lübeck, ^bInnere Medizin/Kardiologie, Herzzentrum Lahr/Baden, Lahr, Deutschland

Article

Publisher ID: 7034 Other ID: Cardiology 2000;93:249–253

DOI: 10.1159/000007034

PubMed ID: 11025351

Copyright statement: © 2000 S. Karger AG, Basel

License:

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Page count

Figures: 2, Tables: 2, References: 17, Pages: 5

Product

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Categories

Subject: Coronary Care