+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Normal Osmotic Threshold for Vasopressin Release in the Hyponatremia of Hypothyroidism


      Hormone Research in Paediatrics

      S. Karger AG

      Hypothyroidism, Osmotic threshold, Hyponatremia

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          To explore a possible downward setting of the hypothalamic osmoreceptors in the hyponatremia of hypothyroidism, 4 adolescent patients with hypothyroidism were studied. Plasma and urine osmolality were measured on random paired simultaneous samples, and following a water load. The osmotic threshold was determined by the isovolemic infusion of hypertonic NaCl, and compared to the osmotic threshold of 6 healthy subjects. Random paired urine and plasma osmolality revealed inappropriately high urine osmolality for the given plasma osmolality. A water load produced a normal dilution of urine. Osmotic threshold was found at plasma osmolality of 286–287 mosm/kg, compared to 286.7 ± 1.0 in 6 normal individuals. It is concluded that none of the known types of the syndrome of inappropriate ADH secretion could account for the hyponatremia in the hypothyroid patients, and that patients with hypothyroidism have normal osmoreceptors as measured by the osmotic threshold test.

          Related collections

          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          26 November 2008
          : 17
          : 3
          : 128-133
          Department of Pediatrics, A. Rambam Medical Center and the Pediatric Endocrine Unit, Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
          179687 Horm Res 1983;17:128–133
          © 1983 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6


          Comment on this article