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      ERM proteins and merlin: integrators at the cell cortex.

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          Abstract

          A fundamental property of many plasma-membrane proteins is their association with the underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and other plasma-membrane processes, including endocytosis and exocytosis. The ezrin-radixin-moesin (ERM) proteins are crucial components that provide a regulated linkage between membrane proteins and the cortical cytoskeleton, and also participate in signal-transduction pathways. The closely related tumour suppressor merlin shares many properties with ERM proteins, yet also provides a distinct and essential function.

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          Author and article information

          Journal
          Nat Rev Mol Cell Biol
          Nature reviews. Molecular cell biology
          Springer Science and Business Media LLC
          1471-0072
          1471-0072
          Aug 2002
          : 3
          : 8
          Affiliations
          [1 ] Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. apb5@cornell.edu
          Article
          nrm882
          10.1038/nrm882
          12154370
          9bc4244b-a117-45a9-9baf-d17a286b8540
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