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      A single in-vivo exposure to delta 9THC blocks endocannabinoid-mediated synaptic plasticity.

      Nature neuroscience

      physiology, Animals, drug effects, Synapses, Nucleus Accumbens, Neuronal Plasticity, Mice, In Vitro Techniques, Hippocampus, Endocannabinoids, administration & dosage, Dronabinol, Dose-Response Relationship, Drug, antagonists & inhibitors, Cannabinoid Receptor Modulators

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          Abstract

          Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and hippocampus in vitro. This effect is reversible within 3 days and is associated with a transient modification in the functional properties of cannabinoid receptors.

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          Journal
          10.1038/nn1251
          15146190

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