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      Single early instillation of mitomycin C and urinary alkalinization in low-risk non-muscle-invasive bladder cancer: a preliminary study

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          Abstract

          Background

          The purpose of this study was to determine the effectiveness of a single early instillation of mitomycin C (MMC) after transurethral resection of bladder tumor (TURBT) together with urinary alkalinization in patients with low-risk non-muscle-invasive bladder cancer (NMIBC).

          Methods

          Between February 2006 and November 2010, patients diagnosed as having a primary bladder tumor were randomized into standard and optimized treatment groups. The treatment groups were formed prospectively from patients with NMIBC according to results of pathological examination postoperatively, whereas the control group was formed retrospectively. Patients in the standard group (n = 11) were given intravesical MMC 40 mg in the first 6 hours after TURBT, while the patients in the optimized group (n = 15) underwent urinary alkalinization prior to MMC. In the control group (n = 23), no drug treatment was given. The patients were followed after surgery at months 3 and 12, and then annually for the first 5 years using cystoscopy and ultrasound. Time to recurrence and recurrence-free survival rates were calculated.

          Results

          There were no statistically significant differences between the standard and optimized groups, between the control and optimized groups, or between the control and standard groups in terms of mean recurrence-free survival rates ( P = 0.132, 0.645, and 0.173, respectively). The mean time to recurrence was 34.8 (range 28.5–41.1) months in the optimized group and 51.8 (range 44.3–59.2) months in the control group. There was no recurrence during the follow-up period in the standard group.

          Conclusion

          The results of this preliminary study could not demonstrate the efficacy of urinary alkalinization before a single dose of early MMC following TURBT to increase the effectiveness of the MMC, so we did not continue the study further.

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          Author and article information

          Journal
          Drug Des Devel Ther
          Drug Des Devel Ther
          Drug Design, Development and Therapy
          Dove Medical Press
          1177-8881
          2013
          28 December 2012
          : 7
          : 1-6
          Affiliations
          Department of Urology, Diskapı Yildirim Beyazit Training and Research Hospital, Ministry of Health, Ankara, Turkey
          Author notes
          Correspondence: Hakki Ugur Ozok, Kardelen Mah 2066, sok Siyasal-2 Sit 83 Batıkent, Yenimahalle, Ankara 06370 Turkey, Tel +90 54 2242 4660, Fax +90 31 2255 2086, Email drozok@ 123456gmail.com
          Article
          dddt-7-001
          10.2147/DDDT.S39541
          3536351
          23300343
          © 2013 Ersoy et al, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          Categories
          Original Research

          Pharmacology & Pharmaceutical medicine

          alkalinization, bladder, mitomycin c, tumor

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