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Oleate rescues INS-1E β-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response.
Nov 29 2013
ATF6,
Apoptosis,
Beta cell,
Bip/Grp78,
C/EBP homologous protein,
Chop,
ER,
ER stress,
FFA,
Grp94,
IRE1,
MUFA,
Oleate,
PERK,
Palmitate,
Pdi,
SCD1,
SFA,
UPR,
X-box-binding protein 1,
Xbp1,
activating-transcription-factor 6,
eIF2α,
endoplasmic reticulum,
eukaryotic initiation factor 2α,
free fatty acid,
glucose-regulated protein 94kDa,
immunoglobulin heavy-chain binding protein,
inositol-requiring-enzyme1,
monounsaturated fatty acid,
protein disulfide isomerase,
protein-kinase-regulated-by-RNA-like-ER-associated-kinase,
saturated fatty acid,
stearoyl-CoA desaturase 1,
unfolded protein response
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Abstract
Saturated free fatty acids (FFAs), such as palmitate, cause β-cell apoptosis whereas unsaturated FFAs, e.g. oleate, are not harmful. The toxicity of palmitate could be mediated through endoplasmic reticulum (ER) stress which triggers the activation of a signal responding cascade also called unfolded protein response (UPR). We investigated whether or not palmitate induced β-cell apoptosis through UPR activation and whether or not oleate as a monounsaturated fatty acid could counteract these effects.
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Author and article information
ATF6,Apoptosis,Beta cell,Bip/Grp78,C/EBP homologous protein,Chop,ER,ER stress,FFA,Grp94,IRE1,MUFA,Oleate,PERK,Palmitate,Pdi,SCD1,SFA,UPR,X-box-binding protein 1,Xbp1,activating-transcription-factor 6,eIF2α,endoplasmic reticulum,eukaryotic initiation factor 2α,free fatty acid,glucose-regulated protein 94kDa,immunoglobulin heavy-chain binding protein,inositol-requiring-enzyme1,monounsaturated fatty acid,protein disulfide isomerase,protein-kinase-regulated-by-RNA-like-ER-associated-kinase,saturated fatty acid,stearoyl-CoA desaturase 1,unfolded protein response
ATF6, Apoptosis, Beta cell, Bip/Grp78, C/EBP homologous protein, Chop, ER, ER stress, FFA, Grp94, IRE1, MUFA, Oleate, PERK, Palmitate, Pdi, SCD1, SFA, UPR, X-box-binding protein 1, Xbp1, activating-transcription-factor 6, eIF2α, endoplasmic reticulum, eukaryotic initiation factor 2α, free fatty acid, glucose-regulated protein 94kDa, immunoglobulin heavy-chain binding protein, inositol-requiring-enzyme1, monounsaturated fatty acid, protein disulfide isomerase, protein-kinase-regulated-by-RNA-like-ER-associated-kinase, saturated fatty acid, stearoyl-CoA desaturase 1, unfolded protein response