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      Adaptation of Hexose Uptake by the Rat Jejunum Induced by the Perfusion of Sugars into the Distal Ileum

      Digestion

      S. Karger AG

      Hexose absorption, Rat jejunum, Active transport

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          Abstract

          The effects of perfusing solutions of different composition into the distal ileum of the rat, on glucose or galactose absorption from the jejunum has been determined in vivo. The rate of glucose absorption via the active, phlorhizin-sensitive pathway was increased significantly when either glucose or maltose were present in the lower ileum. In contrast, the presence of galactose, lactose and fructose produced only minimal effects on active glucose absorption. The phlorhizin-insensitive component of glucose absorption was unaffected by the presence of sugar in the distal region. Perfusion of glucose into the ileum enhanced the active uptake of the poorly metabolized hexose, galactose, from the jejunum. The administration of cycloheximide abolished the increase in active glucose absorption induced by distal maltose perfusion. The response to distal glucose (a) required the sugar to be perfused for a minimum of 3 h before increases in absorption became significant, and (b) was not dependent on distal glucose absorption by the phlorhizin-sensitive pathway. The possible mechanisms involved in this adaptive response are discussed. The enhancement of jejunal absorption may be important in man in conditions where glucose is present at abnormally high levels in the distal ileum.

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          Author and article information

          Journal
          DIG
          Digestion
          10.1159/issn.0012-2823
          Digestion
          S. Karger AG
          0012-2823
          1421-9867
          1985
          1985
          28 January 2009
          : 31
          : 1
          : 25-30
          Affiliations
          Department of Physiology, Royal Free Hospital School of Medicine, London, England
          Article
          199173 Digestion 1985;31:25–30
          10.1159/000199173
          3979678
          © 1985 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

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