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      Cushing's syndrome.

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          Abstract

          Cushing's syndrome results from lengthy and inappropriate exposure to excessive glucocorticoids. Untreated, it has significant morbidity and mortality. The syndrome remains a challenge to diagnose and manage. Here, we review the current understanding of pathogenesis, clinical features, diagnostic, and differential diagnostic approaches. We provide diagnostic algorithms and recommendations for management.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          Elsevier BV
          1474-547X
          0140-6736
          May 13 2006
          : 367
          : 9522
          Affiliations
          [1 ] Division of Clinical Sciences, University of Sheffield, Northern General Hospital, Sheffield, UK. j.newellprice@sheffield.ac.uk
          Article
          S0140-6736(06)68699-6
          10.1016/S0140-6736(06)68699-6
          16698415
          9bf25234-880b-44a5-8df2-f6bc88afcefd
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