The Volta Grande Environmental Unity represents one of the few remnants of Cerrado protected by a reserve in the Triângulo Mineiro region, municipalities of Conceição das Alagoas (19°55' S, 48°23' W) and Miguelópolis (20°12' S, 48°03' W), in the states of Minas Gerais and São Paulo, respectively. The mammalian fauna of this reserve was inventoried between 2003 and 2004 to generate estimates about taxonomic composition, richness, and abundance of species. A sampling effort of 832 trapping-nights resulted in 24 species recorded. Cumulative curves suggest that the overall inventory is not complete and that more species are likely to be registered. The majority of species recorded is widespread along the Cerrado, but include some noteworthy records of endangered species, such as the Giant anteater (Myrmecophaga tridactyla) and the Manned wolf (Chrysocyon brachyurus). The record of the arboreal cricetid rodent Oecomys bicolor represents a slight extension of the southeastern limit of its distribution.