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      Quantitative EEG and Statistical Mapping of Wakefulness and REM Sleep in the Evaluation of Mild to Moderate Alzheimer’s Disease

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          Abstract

          Statistical probability mapping was used to quantify and localize EEG differences between 27 patients with Alzheimer’s disease (AD) and 25 age- and gen-er-matched controls. Differences in mean activity in four EEG frequency bands (delta, theta, alpha, beta) for wakefulness and for REM sleep were examined, t-statistic maps clearly highlighted common pattern anomalies in AD patients in the two states. More specifically, Alzheimer patients were more affected than control subjects in parieto-temporal and frontal regions. These differences were more prominent in REM sleep and consisted primarily in an increase in absolute delta and theta activities, and a decrease in absolute alpha and beta activities. Discriminant analysis, using a ratio of slow over fast frequencies, yielded a classification rate of 90.4% (sensitivity 81.5%, specificity 100%) for REM sleep. For wakefulness, the same measure allowed correct classification of 80.8% of the subjects (sensitivity 66.7%, specificity 96%).

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          Author and article information

          Journal
          ENE
          Eur Neurol
          10.1159/issn.0014-3022
          European Neurology
          S. Karger AG
          0014-3022
          1421-9913
          1997
          1997
          14 February 2008
          : 37
          : 4
          : 219-224
          Affiliations
          aCentre d’étude du sommeil, Hôpital du Sacré-Cœur and Département de Psychiatrie, Université de Montreal, and bMcGill Center for Studies in Aging, McGill University, Montréal, Canada
          Article
          117446 Eur Neurol 1997;37:219–224
          10.1159/000117446
          9208261
          9bf99cdc-8b25-492d-8753-6cae3ba0f47e
          © 1997 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 12 March 1996
          : 07 November 1996
          Page count
          Pages: 6
          Categories
          Original Paper

          Geriatric medicine,Neurology,Cardiovascular Medicine,Neurosciences,Clinical Psychology & Psychiatry,Public health
          Quantitative EEG,Brain mapping,Alzheimer’s disease,REM sleep,Wakefulness

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