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      Breakdown of the Blood-Retinal Barrier after Radiofrequency-Induced Ocular Hyperthermia

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          Abstract

          To study the possible application of hyperthermia in the treatment of proliferative vitreoretinopathy (PVR), we induced hyperthermia in 15 normal rabbit eyes by a radiofrequency capacitive heating device. The retinal surface of each eye was warmed to a presumed temperature of 41 or 43 °C for 30 min. The thermal effect on the blood-retinal barrier (BRB) was evaluated before and 2 h after the hyperthermic regimen by means of vitreous fluorophotometry. Heat treatment to 43 °C at the retinal surface for 30 min increased the fluorescein leakage compared with the 41 °C treatment. This finding suggests that retinal hyperthermia at 43 °C for 30 min may cause breakdown of the BRB.

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          Author and article information

          Journal
          OPH
          Ophthalmologica
          10.1159/issn.0030-3755
          Ophthalmologica
          S. Karger AG
          0030-3755
          1423-0267
          1993
          1993
          01 April 2010
          : 206
          : 2
          : 107-110
          Affiliations
          Department of Ophthalmology, Kyoto University Faculty of Medicine, Kyoto, Japan
          Article
          310372 Ophthalmologica 1993;206:107–110
          10.1159/000310372
          8272325
          © 1993 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Original Paper

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