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      ABO/Rh Blood Groups and Risk of HIV Infection and Hepatitis B Among Blood Donors of Abidjan, Côte D’ivoire

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          Abstract

          Hepatitis B and HIV infection are two viral infections that represent real global public health problems. In order to improve their management, some hypotheses suggest that genetic predispositions like ABO and Rh blood groups would influence the occurrence of these diseases.

          The aim of the present study was to examine the association between ABO and Rhesus blood groups and the susceptibility to HIV infection and hepatitis B.

          We conducted a cross-sectional and analytical study in a population of voluntary blood donors in the Blood Transfusion Center of Abidjan. All blood donors who donated blood between January and June 2014 were tested for HBs antigen and anti-HIV antibodies (ELISA tests) and were ABO typed.

          The total number of examined blood donors during this period was 45,538, of which 0.32% and 8.07% were respectively infected with HIV and hepatitis B virus. O-group donors were more infected than non-O donors.

          Our study is an outline concerning the search for a link between ABO and Rh blood groups and hepatitis B and HIV infection. Further studies should be conducted to confirm the interaction between these two infections and contribute to the search for new therapeutic approaches.

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          Most cited references 17

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          Blood groups and susceptibility to disease: a review.

           David Roberts (1957)
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            [Prevalence of HBs antigen in blood donors in the Bouaké regional centre of blood transfusion in 2001].

             O Kra,  N N'Dri,  E Ehui (2007)
            A prospective cross-sectional study was conducted in the regional center of blood transfusion in Bouaké from December 1, 2001 to February 28, 2002. One thousand two hundred thirty one new blood donors were tested. HBs Antigen detection was made according to ELISA technique (Hepanostika HBs Ag Uni-Form II). HBs Antigen prevalence in blood donors in Bouaké was 12.5%. One hundred fifty four blood donors were tested positive and were divided into 131 males (85%) and 23 females (15%). Their average age was 27, 5 years old (18-65 years). HBs Antigen carriage rate was lower in females and students. They were mainly pupils (62%) and had risk factors of hepatitis B infection (intramuscular injection, multiple sexual partners, unsafe sex). HBs Antigen carriage rate in blood donors is high in Bouaké and justifies the systematic screening of this Antigen in any blood donor to reduce the transfusion risk. On the other hand, it is necessary to modify the blood collection strategy in order to make the most of the donation and to decrease the residual risk.
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              ABO blood groups distribution in relation to hepatitis B surface antigen and the presence of lipoidophil antibodies.

               A Emeribe,  G Ejezie (1992)
              Three hundred and thirty donors were screened for HBs Ag using direct passive haemagglutination and the presence of Lipoidophil antibodies as detected by VDRL test. Blood group O donors had the highest HBs Ag prevalence rate of 4.3% as against the 0% frequency for group AB donors. There were no significant association between ABO blood group distribution and the presence of HBs Ag (P greater than 0.05). 11 donors in all were positive for HBs Ag giving a total prevalence of 3.3%. The sera of 27 blood donors (8.2%) contained lipoidophil antibodies. The highest percentage of VDRL test positivity was in blood group B donors (22.7%) followed by group O (9.1%). None of the 6 group AB donors had a reactive sera. Test of significance showed that there was no association between ABO distribution and the presence of lipoidophil antibodies. In conclusion, it is stated that since none of the blood donors that was reactive to the VDRL reagin carried HBs Ag, hepatitis virus B unlike other viral infection, may not elicit the production of lipoidophil antibodies.
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                Author and article information

                Journal
                Eur J Microbiol Immunol (Bp)
                Eur J Microbiol Immunol (Bp)
                EUJMI
                European Journal of Microbiology & Immunology
                Akadémiai Kiadó (Budapest )
                2062-509X
                2062-8633
                18 September 2015
                September 2015
                : 5
                : 3
                : 205-209
                Affiliations
                [1 ] Immunology–Allergology Department, UFR Medical Sciences, Felix Houphouet Boigny University , Abidjan, Côte d’Ivoire
                [2 ] Faculty of Pharmaceutical and Biological Sciences, Felix Houphouet Boigny University , Abidjan, Côte d’Ivoire
                [3 ]National Public Health Laboratory , Abidjan, Côte d’Ivoire
                [4 ] Bacteriology–Virology Department, Central Laboratory of the University Hospital of Yopougon , Côte d’Ivoire
                [5 ] Laboratory of Microbiology – CNR/HIV, University Hospital Sylvanus Olympio , Togo
                Author notes
                * Immunology–Allergology Department, UFR Medical Sciences, Felix Houphouet Boigny University, Abidjan, Côte d’Ivoire; (225) 01 05 07 34; lilianesiransy@ 123456yahoo.fr

                Conflicts of interest: The authors declare that they have no conflicts of interest.

                Article
                10.1556/1886.2015.00029
                4598888
                © 2015, The Author(s)

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                Page count
                Figures: 1, Tables: 3, Equations: 0, References: 20, Pages: 5
                Categories
                Original Article

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