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      Homocysteinic acid causes oxidative stress in lymphocytes by potentiating toxic effect of NMDA.

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      Bulletin of experimental biology and medicine

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          Abstract

          Short-term incubation of lymphocytes with homocysteine or its oxidation product homocysteinic acid increased the formation of reactive oxygen species and cell necrosis (in case of homocysteinic acid). Effective concentration of homocysteine and homocysteinic acid (500 microM) significantly surpassed the level observed during hyperhomocysteinemia. The addition of homocysteinic acid in a nontoxic concentration of 100 microM potentiated the toxic effect of NMDA and led to massive cell death. During hyperhomocysteinemia the amount of these metabolites in the blood was much higher than in the brain. Oxidative stress produced by these substances can result from activation of NMDA glutamate receptors that were recently detected on lymphocytes.

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          Author and article information

          Journal
          Bull. Exp. Biol. Med.
          Bulletin of experimental biology and medicine
          0007-4888
          0007-4888
          Jul 2005
          : 140
          : 1
          Affiliations
          [1 ] Laboratory of Clinical Neurochemistry, Institute of Neurology, Russian Academy of Medical Sciences, Moscow. aaboldyrev@yahoo.com
          Article
          doi
          16254614
          9c1a9414-7df0-4e59-ac16-375023dceaf6
          History

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