Correlation between BMI and metagenomics concentration of gut microbiota of college students in Inner Mongolia

Abstract

Objective To explore the correlation between BMI and gut microbiota of college students in Inner Mongolia, and to provide a reference basis for revealing the relationship between intestinal flora and obesity.

Methods Totally 88 college students from Inner Mongolia Medical University were enrolled, Height and weight were measured, and the feces samples were collected. The bacterial metagenome was extracted from dry feces samples for the concentration detection in per gram of dry feces, expressed as µg/µL. Correlation between BMI and metagenomics concentration of gut microbiota was statistically analyzed. Meanwhile, the metagenomics concentration of gut microbiota in different BMI groups was compared with each other.

Results There was a negative correlation between BMI and the metagenomics concentration of gut microbiota ( r = –0.27, P<0.05). Significant difference in the concentration of gut microflora was observed between the normal group and the obesity group, the normal group and the overweight/obesity group ( F = 3.62, P<0.05). Among the female volunteers, there were significant differences between normal group and overweight group, between normal group and obesity group ( F = 1.87, P<0.05). No significant differences in metagenomics concentration of gut microbiota were found in different BMI groups ( F = 0.60, P>0.05)

Conclusion There is a correlation between BMI and gut microbiota of college students in Inner Mongolia, the concentration of gut microflora metagenome in overweight and obese people decreased significantly.

Abstract

【摘要】 目的 探索内蒙古地区在校大学生体质量指数（BMI)与肠道菌群的关联性, 为揭示肠道菌群与肥胖之间的关联 性提供参考依据。 方法 以内蒙古医科大学为试点, 通过招募方式共收集88名志愿者。测量研究对象的身高和体重, 并 收集粪便样本。提取干粪便样本中的细菌宏基因组, 并检测干粪便细菌宏基因组质量浓度(µg/µL)。统计分析BMI与肠 道菌群宏基因组质量浓度的相关性, 并比较不同BMI组的肠道菌群宏基因组质量浓度差异。 结果 大学生BMI与肠道菌 群的宏基因组质量浓度呈负相关( r = –0.27, P<0.05)。不同BMI大学生的肠道菌群宏基因组质量浓度差异有统计学意义 ( F =3.62, P<0.05)。分性别分析, 女生中, 不同BMI的肠道菌群宏基因组质量浓度差异有统计学意义（ F = 1.87, P<0.05), 两两比较正常组与超重组、正常组与肥胖组差异均有统计学意义（ P值均<0.05);男生中, 不同BMI的肠道菌群宏基因组 质量浓度差异无统计学意义（ F =0.60, P>0.05)。 结论 内蒙古地区在校大学生BMI与其肠道菌群具有关联性, 超重及肥 胖人群肠道菌群宏基因组质量浓度显著降低。