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      Marked Reduction in Gonadal Steroid Hormone Levels in Rats Treated Neonatally with Monosodium L-Glutamate: Further Evidence for Disruption of Hypothalamic-Pituitary-Gonadal Axis Regulation

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          Abstract

          Serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, estradiol-17β and testosterone were determined in adult rats that were treated in the neonatal period with monosodium L-glutamate (MSG) which has previously been shown to reliably produce destruction of arcuate nucleus perikarya. MSG-treated males had significantly smaller accessory sexual organs (seminal vesicles and ventral prostate) and testes and had significantly lower serum concentrations of FSH and testosterone than sex-matched controls. MSG-treated females had significantly lower serum concentrations of LH, FSH and estradiol-17β. Prolactin levels in MSG-treated rats were no different than sex-matched controls. This marked reduction in gonadal steroid levels (168%) and inappropriately low gonadotropin levels further characterizes the deficit of feedback regulation in the hypothalamic-pituitary-gonadal axis in MSG-treated rats.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1981
          1981
          26 March 2008
          : 33
          : 5
          : 265-267
          Affiliations
          aBiological Sciences Research Center, University of North Carolina School of Medicine, Chapel Hill, N.C., USA; bLaboratory of Organ Function and Toxicology, and cLaboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, N.C., USA.
          Article
          123243 Neuroendocrinology 1981;33:265–267
          10.1159/000123243
          6795522
          © 1981 S. Karger AG, Basel

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          Page count
          Pages: 3
          Categories
          Original Paper

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