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      Marked Reduction in Gonadal Steroid Hormone Levels in Rats Treated Neonatally with Monosodium L-Glutamate: Further Evidence for Disruption of Hypothalamic-Pituitary-Gonadal Axis Regulation

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          Serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, estradiol-17β and testosterone were determined in adult rats that were treated in the neonatal period with monosodium L-glutamate (MSG) which has previously been shown to reliably produce destruction of arcuate nucleus perikarya. MSG-treated males had significantly smaller accessory sexual organs (seminal vesicles and ventral prostate) and testes and had significantly lower serum concentrations of FSH and testosterone than sex-matched controls. MSG-treated females had significantly lower serum concentrations of LH, FSH and estradiol-17β. Prolactin levels in MSG-treated rats were no different than sex-matched controls. This marked reduction in gonadal steroid levels (168%) and inappropriately low gonadotropin levels further characterizes the deficit of feedback regulation in the hypothalamic-pituitary-gonadal axis in MSG-treated rats.

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          Author and article information

          S. Karger AG
          26 March 2008
          : 33
          : 5
          : 265-267
          aBiological Sciences Research Center, University of North Carolina School of Medicine, Chapel Hill, N.C., USA; bLaboratory of Organ Function and Toxicology, and cLaboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, N.C., USA.
          123243 Neuroendocrinology 1981;33:265–267
          © 1981 S. Karger AG, Basel

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          Pages: 3
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