Objective: The aim of this study was the evaluation of analgesic drugs prescription as an epidemiological indicator of average annual percentage change (AAPC) in geriatric and palliative patients in the period 2016-2017. Design: Descriptive study. Participants: Geriatric and palliative patients. Methods: We analysed 12,889 analgesic drugs within the period of two years (2016-2017). Epidemiological indicator of AAPC was proposed for analysis of analgesic drugs prescription.Results: The highest percentage from all analgesic drugs under our evaluation was Acetylsalicylic Acid in 1st half of 2017 (54.3%) with 0.05% decrease compared to 2016. The significant decrease or increase of the AAPC of other analgesic drugs prescription was not observed in geriatric and palliative patients. Conclusion: The regular reassessments of analgesic drug prescriptions is in line with the regular assessment of patients’ needs are required.