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      MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1.

      Gastroenterology

      Adult, Aged, Carcinoma, Hepatocellular, genetics, virology, Down-Regulation, Female, Gene Expression Regulation, Neoplastic, Hepatitis B, Chronic, complications, Hepatitis C, Chronic, Humans, Liver Neoplasms, Luciferases, Male, MicroRNAs, Middle Aged, Oligonucleotide Array Sequence Analysis, Stathmin

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          Abstract

          Recent studies have emphasized causative links between microRNA (miRNA) deregulations and cancer development. In hepatocellular carcinoma (HCC), information on differentially expressed miRNA remained largely undefined. Array-based miRNA profiling was performed on HCC cells that were derived from chronic carriers of hepatitis B virus (HBV) and hepatitis C virus (HCV), and nonviral-associated patients. Specific microRNA (miR)-223 and miR-222 deregulations were verified in an independent series of tumors. The functional effect of miR-223 was examined further. An integrative analysis of messenger RNA (mRNA) array with in silico predictions defined potential downstream targets of miR-223. A luciferase reporter assay was conducted to confirm target association. Distinct up-regulations of miR-222, miR-221, and miR-31, and down-regulations of miR-223, miR-126, and miR-122a were identified. Further investigations suggested the highly deregulated miR-223 and miR-222 could unequivocally distinguish HCC from adjacent nontumoral liver, irrespective of viral associations (P

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          Journal
          18555017
          10.1053/j.gastro.2008.04.003

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