Elevated prefrontal cortex GABA in patients with major depressive disorder after TMS treatment measured with proton magnetic resonance spectroscopy.

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Abstract

GABAergic and glutamatergic neurotransmitter systems are central to the pathophysiology of depression and are potential targets of repetitive transcranial magnetic stimulation (rTMS). We assessed the effect of 10-Hz rTMS over the left dorsolateral prefrontal cortex (DLPFC) of patients with major depressive disorder on the levels of medial prefrontal cortex (MPFC) γ-aminobutyric acid (GABA) and the combined resonance of glutamate and glutamine (Glx) as assessed in vivo with proton magnetic resonance spectroscopy ((1)H MRS).

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Journal

Journal ID (iso-abbrev): J Psychiatry Neurosci

Title: Journal of psychiatry & neuroscience : JPN

ISSN (Electronic): 1488-2434

ISSN (Print): 1180-4882

Publication date (Electronic): Apr 2016

Volume: 41

Issue: 3

Affiliations

[1 ] From the Department of Psychiatry, Weill Cornell Medical College, New York, USA (Dubin, Liston); the Brain and Mind Research Institute, Weill Cornell Medical College, New York, USA (Dubin, Liston); the Department of Radiology, Weill Cornell Medical College, New York, USA (Mao, Kang, Shungu); the Department of Healthcare Policy and Research, Weill Cornell Medical College, New York, USA (Banerjee); the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA (Lapidus); and the Johns Hopkins University, Baltimore, USA (Goodman).

Article

Publisher Item ID: 10.1503/jpn.150223

DOI: 10.1503/jpn.150223

PMC ID: 4853214

PubMed ID: 26900793

SO-VID: 9c304e02-47f5-4999-b9d5-aa11096a22a3

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Elevated prefrontal cortex GABA in patients with major depressive disorder after TMS treatment measured with proton magnetic resonance spectroscopy.

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