- Record: found
- Abstract: found
- Article: found
Decreased lung function is associated with risk of developing non-alcoholic fatty liver disease: A longitudinal cohort study
research-article
Author(s):
Jae-Uk Song
1 ,
Yoonjung Jang
1 ,
Si-Young Lim
1 ,
Seungho Ryu
2
,
3
,
4 ,
Won Jun Song
5 ,
Christopher D. Byrne
6 ,
Ki-Chul Sung
7
,
*
Publication date (Electronic):
23 January 2019
Journal:
PLoS ONE
Publisher:
Public Library of Science
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Abstract
Background Decreased lung function is associated with non-alcoholic fatty liver disease (NAFLD), based on linking mechanisms such as insulin resistance and systemic inflammation However, its association with the risk of developing NAFLD is unclear. Our aim was to investigate whether baseline lung function is associated with incident NAFLD in middle-aged healthy Koreans. Methods A cohort study of 96,104 subjects (mean age: 35.7 years) without NAFLD were followed up from 2002 to 2015. NAFLD was diagnosed by ultrasound after the exclusion of other possible causes of liver diseases. Baseline percent predicted forced expiratory volume in one second (FEV1%) and forced vital capacity (FVC%) were categorized in quartiles. Adjusted hazard ratios (aHR) and 95% confidence intervals (CIs) (using the highest quartile as reference) were calculated for incident NAFLD at follow-up, controlling for covariates and potential confounders. Results During 579,714.5 person-years of follow-up, 24,450 participants developed NAFLD (incidence rate, 42.2 per 1,000 person-years). The mean follow-up period was 5.9±3.4 years. Regardless of smoking history, the risk for incident NAFLD increased with decreasing quartiles of FEV1 (%) and FVC (%) in a dose-response manner (p for trend<0.001). In never smokers, the aHRs (95% CIs) for incident NAFLD were 1.15 (1.08–1.21), 1.11 (1.05–1.18), and 1.08 (1.02–1.14) in quartiles 1–3 for FEV1 (%) and 1.12 (1.06–1.18), 1.11 (1.05–1.18), and 1.09 (1.03–1.15) in quartiles 1–3 for FVC (%), compared with the highest quartile reference. Similar inverse association was present in smoke-exposed subjects (aHR for incident NAFLD were 1.14, 1.21, 1.13 and 1.17, 1.11, 1.09 across FEV1(%) and FVC(%) quartile in increasing order, respectively). Conclusions Reduced lung function was a risk factor for incident NAFLD in a large middle-aged Korean cohort with over half a million person-years of follow-up.
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Most cited references41
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Relationship between sarcopenia and nonalcoholic fatty liver disease: the Korean Sarcopenic Obesity Study.
Ho Hong, Soon Young Hwang, Hae Yoon Choi … (2014)
Previous studies have shown that nonalcoholic fatty liver disease (NAFLD) and sarcopenia may share pathophysiological mechanisms, such as insulin resistance, inflammation, vitamin D deficiency, and decreased physical activity. However, their direct relationship has not been investigated. The association between NAFLD and sarcopenia was examined in 452 apparently healthy adults enrolled in the Korean Sarcopenic Obesity Study (KSOS), an ongoing prospective observational cohort study. The liver attenuation index (LAI), which was measured using abdominal computed tomography (CT), was used as a parameter for the diagnosis of NAFLD. Sarcopenia was defined using a skeletal muscle mass index (SMI) [SMI (%) = total skeletal muscle mass (kg) / weight (kg) × 100] that was measured by dual energy X-ray absorptiometry (DXA). After adjusting for age and sex, both SMI and LAI were negatively correlated with the homeostasis model assessment of insulin resistance (HOMA-IR) (P < 0.001) and high sensitivity C-reactive protein (hsCRP) (P < 0.001) as well as brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness. Furthermore, SMI and LAI had positive relationships with high-density lipoprotein (HDL)-cholesterol, but both had a negative relationship with triglyceride, alanine aminotransferase (ALT), and total body fat. In a multiple logistic regression analysis, the odds ratio for NAFLD risk was 5.16 (95% confidence interval [CI] = 1.63-16.33) in the lowest quartile of SMI compared to the highest after adjusting for potential confounding factors.
Author and article information
Contributors
Jae-Uk Song:
ORCID: http://orcid.org/0000-0003-4597-7037
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Writing – original
draftRole: Writing – review & editing
Yoonjung Jang: Role: Writing – original draft
Si-Young Lim: Role: Writing – review & editing
Seungho Ryu: Role: Data curationRole: Formal analysisRole: Writing – review & editing
Won Jun Song: Role: Writing – review & editing
Christopher D. Byrne: Role: ConceptualizationRole: Writing – review & editing
Ki-Chul Sung:
ORCID: http://orcid.org/0000-0001-5630-2145
Role: ConceptualizationRole: Writing – original draftRole: Writing – review & editing
Giovanni Targher: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
23
January
2019
Publication date Collection: 2019
Volume: 14
Issue: 1
Electronic Location Identifier: e0208736
Affiliations
[1
]
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine,
Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic
of Korea
[2
]
Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan
University School of Medicine, Seoul, Republic of Korea
[3
]
Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan
University School of Medicine, Seoul, Republic of Korea
[4
]
Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University,
Seoul, Republic of Korea
[5
]
Department of Critical Care Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University
School of Medicine, Seoul, Republic of Korea
[6
]
Nutrition and Metabolism Group, Southampton General Hospital, University of Southampton,
Southampton, UK Southampton National Institute for Health Research, Biomedical Research
Centre, Southampton General Hospital, University of Southampton, Southampton, United
Kingdom
Author notes
* E-mail:
kcmd.sung@
123456samsung.com
Author information
Jae-Uk Song
http://orcid.org/0000-0003-4597-7037
Ki-Chul Sung
http://orcid.org/0000-0001-5630-2145
Article
Publisher ID: PONE-D-18-27705DOI: 10.1371/journal.pone.0208736
PMC ID: 6343945
PubMed ID: 30673698
SO-VID: 9c30998d-b65b-49b9-9ca5-c466c577ca00
Copyright © © 2019 Song et al
License:
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
History
Date
received
: 22
September
2018
Date
accepted
: 22
November
2018
Page count
Figures: 2,
Tables: 4,
Pages: 15
Funding
The author(s) received no specific funding for this work.
Categories
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Pulmonology
Subject:
Pulmonary Function
Subject:
Medicine and Health Sciences
Subject:
Gastroenterology and Hepatology
Subject:
Liver Diseases
Subject:
Fatty Liver
Subject:
Biology and Life Sciences
Subject:
Psychology
Subject:
Behavior
Subject:
Habits
Subject:
Smoking Habits
Subject:
Social Sciences
Subject:
Psychology
Subject:
Behavior
Subject:
Habits
Subject:
Smoking Habits
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Diagnostic Radiology
Subject:
Ultrasound Imaging
Subject:
Research and Analysis Methods
Subject:
Imaging Techniques
Subject:
Diagnostic Radiology
Subject:
Ultrasound Imaging
Subject:
Medicine and Health Sciences
Subject:
Radiology and Imaging
Subject:
Diagnostic Radiology
Subject:
Ultrasound Imaging
Subject:
Research and Analysis Methods
Subject:
Bioassays and Physiological Analysis
Subject:
Respiratory Analysis
Subject:
Spirometry
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Lipids
Subject:
Cholesterol
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Signs and Symptoms
Subject:
Inflammation
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Signs and Symptoms
Subject:
Inflammation
Subject:
People and Places
Subject:
Population Groupings
Subject:
Ethnicities
Subject:
Korean People
Custom metadata
Data Availability Due to ethical restrictions imposed by the Institutional Review Board of Kangbuk Samsung
Hospital, the patient data are not available for distribution outside of the Kangbuk
Samsung Hospital. For additional information, please contact JiinAhn (
Jiin57.ahn@
123456samsung.com
) or the Institutional Review Board of Kangbuk Samsung Hospital (contact information
below). - Address: 29 Saemunan-ro, Jongno-Gu, Seoul, Korea (03181) - E-mail:
irb.kbsmc@
123456samsung.com
- Telephone: 82-2-2001-1943, 1945 - Fax: 82-2-2001-1946.
ScienceOpen disciplines: Uncategorized
Data availability:
ScienceOpen disciplines: Uncategorized