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Computing multiple sequence/structure alignments with the T-coffee package.
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Abstract
In this unit, we describe assembly of a multiple sequence alignment using the T-Coffee package. T-Coffee is much more flexible than most related methods (e.g., ClustalW) because it makes it possible to combine many alternative alignments into a single one, based on an estimate of consistency between these alignments. This strategy can be especially useful when one has to decide among the output produced by several alternative methods.