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      Local corticosteroid application blocks transmission in normal nociceptive C-fibres.

      Acta Anaesthesiologica Scandinavica

      Administration, Topical, Animals, Anti-Inflammatory Agents, administration & dosage, pharmacology, Male, Methylprednisolone, analogs & derivatives, Nerve Fibers, drug effects, physiology, Nerve Fibers, Myelinated, Nociceptors, Rats, Rats, Inbred Strains, Synaptic Transmission

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          Abstract

          The effect of a locally applied depot form of a corticosteroid on the electrical properties of nerves was investigated in an experimental model. The segmental transmission in electrically stimulated A-fibres and in C-fibres of the plantar nerve in the anaesthetized rat was utilized. A drop of methylprednisolone acetate or vehicle constituent was placed on the dissected plantar nerve proximal to the stimulating electrodes after recording control responses (A-fibre volley in the sciatic nerve and C-fibre evoked reflex discharge in flexor motoneurons). The corticosteroid was found to suppress the transmission in thin unmyelinated C-fibres but not in myelinated A-beta fibres. The effect was found to be due to the corticosteroid per se. The effect was reversed when the corticosteroid was removed, which suggests a direct membrane action.

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          2167604

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