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      Epstein-Barr virus: more than 50 years old and still providing surprises.

      1 , 2 , 3

      Nature reviews. Cancer

      Springer Nature

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          Abstract

          It is more than 50 years since the Epstein-Barr virus (EBV), the first human tumour virus, was discovered. EBV has subsequently been found to be associated with a diverse range of tumours of both lymphoid and epithelial origin. Progress in the molecular analysis of EBV has revealed fundamental mechanisms of more general relevance to the oncogenic process. This Timeline article highlights key milestones in the 50-year history of EBV and discusses how this virus provides a paradigm for exploiting insights at the molecular level in the diagnosis, treatment and prevention of cancer.

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          Author and article information

          Journal
          Nat. Rev. Cancer
          Nature reviews. Cancer
          Springer Nature
          1474-1768
          1474-175X
          December 2016
          : 16
          : 12
          Affiliations
          [1 ] Warwick Medical School, The University of Warwick, Coventry CV4 7AL, UK.
          [2 ] Department of Oral and Craniofacial Sciences and Oral Cancer Research Coordinating Centre, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
          [3 ] Institute of Cancer and Genomic Medicine, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK.
          Article
          nrc.2016.92
          10.1038/nrc.2016.92
          27687982

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