Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency

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Abstract

Background/Aims: On behalf of the Drug and Therapeutics, and Ethics Committees of the Pediatric Endocrine Society, we sought to update the guidelines published in 2003 on the use of growth hormone (GH). Because idiopathic short stature (ISS) remains a controversial indication, and diagnostic challenges often blur the distinction between ISS, GH deficiency (GHD), and primary IGF-I deficiency (PIGFD), we focused on these three diagnoses, thereby adding recombinant IGF-I therapy to the GH guidelines for the first time. Methods: This guideline was developed following the GRADE approach (Grading of Recommendations, Assessment, Development, and Evaluation). Results: This guideline provides recommendations for the clinical management of children and adolescents with growth failure from GHD, ISS, or PIGFD using the best available evidence. Conclusion: The taskforce suggests that the recommendations be applied in clinical practice with consideration of the evolving literature and the risks and benefits to each individual patient. In many instances, careful review highlights areas that need further research.

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Author and article information

Journal

Journal ID (publisher-id): HRP

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 2016

Publication date (Print): January 2017

Publication date (Electronic): 25 November 2016

Volume: 86

Issue: 6

Pages: 361-397

Affiliations

^aDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, and ^bDivision of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA, ^cDepartment of Pediatrics, University of Washington School of Medicine, and ^dDivision of Endocrinology, Seattle Children's Hospital, Seattle, WA, USA; ^eDivision of Endocrinology, Department of Pediatrics, The McGill University Health Centre, Montreal, QC, Canada; ^fDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, and ^gDivision of Endocrinology and Diabetes, American Family Children's Hospital - Madison, Madison, WI, ^hDivision of Endocrinology, Boston Children's Hospital, and Harvard Medical School, Boston, MA, ⁱThe Warren Alpert Medical School of Brown University, and ^jDivision of Pediatric Endocrinology, Rhode Island Hospital/Hasbro Children's Hospital, Providence, RI, Departments of ^kMedical Ethics and ^lHealth Policy, Perelman School of Medicine, University of Pennsylvania, and ^mDepartment of Medical Ethics and ⁿDivision of General Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, and ^oEvidence-Based Practice Center, Mayo Clinic, Rochester, MN, USA

Author notes

*Assoc. Prof. Adda Grimberg, Perelman School of Medicine, University of Pennsylvania,, Scientific Director, Diagnostic and Research Growth Center, The Children's Hospital, of Philadelphia, 3401 Civic Center Blvd., Suite 11NW30, Philadelphia, PA 19104 (USA), E-Mail Grimberg@email.chop.edu

Article

Publisher ID: 452150 Other ID: Horm Res Paediatr 2016;86:361-397

DOI: 10.1159/000452150

PubMed ID: 27884013

SO-VID: 9c53a01f-94b4-4e60-811b-29d73e2294f1

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 15 July 2016

Date accepted : 30 September 2016

Page count

References: 268, Pages: 37

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