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Antinociceptive activity and chemical composition of constituents from Caragana microphylla seeds
February 2007
February 2007
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Abstract
This investigation was undertaken to ascertain the antinociceptive activity of Caragana
microphylla Lam. seeds and isolate and characterize the constituents. Antinociceptive
activity was screened using acetic acid-induced abdominal constriction in ICR mice.
The 75% ethanol extract and some fractions showed analgesic activity, but the antinociceptive
activity of chloroform fraction was the strongest and was more productive than other
fractions. Seven compounds were isolated from it and identified as: (1) machaeric
acid, (2) beta-sitosterol, (3) stigmasterol, (4) pratol, (5) dehydrocavidine, (6)
formononetin and (7) sucrose. Caragana microphylla Lam. seeds showed analgesic activity,
with the chloroform fraction showing the strongest analgesic activity among the fractions.