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      Carcinoma Verrucoso Oral: Reporte de un Caso Clínico y Revisión de 20 Casos del Instituto de Referencia en Patología Oral (IREPO), Chile Translated title: Oral Verrucous Carcinoma: A Case Report and Review of 20 Cases of the Oral Pathology Referral Institute (IREPO), Chile

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          Abstract

          El carcinoma verrucoso (CV) es una variante rara del carcinoma de células escamosas con características morfológicas y comportamiento específico. El presente estudio relata el caso de una paciente de género femenino, de 68 años de edad, que presenta un carcinoma verrucoso en lengua, indoloro y con 8 meses de evolución. Además, se realizó una breve revisión de casos clínicos del Instituto de Referencia en Patología Oral (IREPO) de la Facultad de Odontología de la Universidad de Chile, diagnosticados entre enero de 1984 y octubre de 2010, encontrándose 20 casos, con un promedio de edad de 70 años, localizados con mayor frecuencia en encía inferior y lengua.

          Translated abstract

          Verrucous carcinoma (VC), a rare variant of squamous cell carcinoma is an established entity with distinctive morphology and specific clinical behavior. The present study describe a case report of a 68-year-old women who presented a tongue verrucous carcinoma, asymptomatic, that had about 8 months of evolution. A brief review of VC cases diagnosed in Oral Pathology Referral Institute (IREPO), Faculty of Odontology, University of Chile, between 1984 and 2010. It was found 20 cases of verrucous carcinoma with a median age of70-years-old, the most common places were lower gingiva and tongue.

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          Verrucous carcinoma of the oral cavity.

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            Verrucous carcinoma of the oral cavity: A clinical and pathological study of 101 cases.

            This paper studies the clinical and pathological predictors of local recurrence and disease-free survival (DFS) in patients with oral verrucous carcinoma (OVC) treated surgically, through a retrospective chart review. Three hundred and two patients with OVC were identified from January 1990 to December 2000, of which, 101 surgically treated patients who fulfilled our inclusion criteria were analyzed. A univariate analysis (UVA) of important prognostic factors, patterns of recurrence, and DFS is reported. Seventy-nine patients were male (M:F ratio, 3.6:1) and the mean age at presentation was 53.9 years (range, 23-90 years). The median follow up was 4.61 years (range, 0.51-14.3 years). The incidence of tobacco chewing, smoking, and alcohol intake was 77%, 42%, and 10%, respectively. Thirty-four patients (33.7%) had either leukoplakia or submucous fibrosis (SMF) on oral cavity examination. Early-stage tumors accounted for 39.7%; while 60.4% were late-stage tumors. On UVA, tumor location, presence of a premalignant lesion, smoking, and positive margins were statistically significant. Sixty-eight percent (19/28) recurred locally. The salvage rate for recurrent tumors was 66.7% (16/28) with a median post-recurrence survival of 16 months (range, 10-83 months). The five year DFS with surgical therapy was 77.6%. OVC has an excellent prognosis with surgical treatment. The significance of positive margins emphasizes the need for adequate surgical resection. Additionally, the presence of either leukoplakia or SMF and tumor location in the upper alveolar-palatal complex is associated with worse outcomes. Neck dissection, if considered, may be limited to a supra-omohyoid neck dissection (SOHND).
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              Oral Verrucous Carcinoma: A Study of 12 Cases

              Objectives: The purpose of this clinical study was to identify a clinical and histopathological relationship between verrucous hyperplasia, verrucous keratosis, and verrucous carcinoma. Methods: We evaluated 12 patients who had developed oral verrucous carcinoma in the past 10 years in a follow-up study. In this study, the diagnostic criteria included clinical and histopathological features of the lesions. Each lesion was examined by a single oral pathologist. Results: All the patients were diagnosed with verrucous carcinoma following excisional biopsy. One patient was diagnosed with verrucous hyperplasia and another with verrucous keratosis in their initial histological findings. Mandibular, posterior alveolar crest, and retromolar trigone were the most affected sites (41.6%), followed by the buccal mucosa (16.6%), the palate (16.6%), the floor of the mouth (16.6%), and the lip (8.3%). No patients had evidence of recurrence after treatment. Conclusions: Verrucous hyperplasia, verrucous keratosis, and verrucous carcinoma may not be distinguished clinically or may coexist, resulting in diagnostic difficulties. It should be kept in mind that verrucous hyperplasia may also develop from leukoplakic lesions, and it may transform into verrucous carcinoma or squamous-cell carcinoma, acting as a potential precancerous lesion.
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                Author and article information

                Journal
                piro
                Revista clínica de periodoncia, implantología y rehabilitación oral
                Rev. Clin. Periodoncia Implantol. Rehabil. Oral
                Sociedad de Periodoncia de Chile. Sociedad de Implantología Oral de Chile. Sociedad de Prótesis y Rehabilitación Oral de Chile. (Santiago, , Chile )
                0719-0107
                December 2010
                : 3
                : 3
                : 132-135
                Affiliations
                [03] orgnameUniversidad de Chile orgdiv1Facultad de Odontología orgdiv2Departamento de Cirugía Bucal y Máxilofacial Chile
                [01] orgnameUniversidad de Chile orgdiv1Facultad de Odontología orgdiv2Departamento de Patología Oral e IREPO Chile
                [02] orgnameUniversidad de Chile orgdiv1Facultad de Odontología orgdiv2Departamento de Patología Oral Chile
                Article
                S0719-01072010000300006 S0719-0107(10)00300306
                10.4067/s0719-01072010000300006
                9c59de11-d2b5-42a9-8423-f9b45ef4cbf3

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 02 November 2010
                : 28 December 2010
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 10, Pages: 4
                Product

                SciELO Chile

                Categories
                Reportes Clínicos

                Verrucous carcinoma,caso clínico,arcinoma verrucoso,case report

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