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      Ghrelin attenuates hyperalgesia and light aversion-induced by nitroglycerin in male rats.

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          Abstract

          Systemic administration of nitroglycerin (NTG) consistently provokes spontaneous-like migraine attacks in migraine sufferers, and in rat it induces hyperalgesia and allodynia. In the present study we modeled migraine headache by intraperitoneal (i.p.) injection of a single dose of NTG, which produced widespread thermal allodynia and mechanical hyperalgesia, photophobia, and increased anxiety-like behaviors and serum concentration of cortisol. Results suggest that the effects of NTG can be largely reversed by administration of ghrelin, which mimics the effects of sumatriptan used as relevant positive therapeutic control in this study. These findings suggest that ghrelin may alleviate some of the negative emotional states associated with migraine and may hold therapeutic potential in treating migraine headache.

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          Author and article information

          Journal
          Neurosci. Lett.
          Neuroscience letters
          Elsevier BV
          1872-7972
          0304-3940
          Sep 06 2016
          : 630
          Affiliations
          [1 ] Neuroscience Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.
          [2 ] Drug Applied Research Center of Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Mohaddesg@tbzmed.ac.ir.
          Article
          S0304-3940(16)30520-1
          10.1016/j.neulet.2016.07.026
          27436480

          Hyperalgesia, Cortisol, Nitroglycerin, Light aversion, Ghrelin

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