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STUDIES ON THE BIOCHEMISTRY OF MITOCHONDRIA AND CELL MORPHOLOGY IN THE NEONATAL SWINE HEPATOCYTE

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      Abstract

      Mitochondrial preparations isolated from neonatal swine hepatocytes show a marked increase in oxidative and concomitant phosphorylative capacity between birth and 2 days postpartum. There are no changes in the coupling parameters (respiratory control ratio and adenosine diphosphate/O ratio) with age. Changes in sedimentation properties in a sucrose gradient suggest qualitative changes in the mitochondria. Some of the lipid measurements (increased phospholipid) might be interpreted as supportive of this suggestion, although most could also be regarded as indicative of quantitative changes (increased number of mitochondria). Electron microscopy of isolated mitochondria and of the hepatocyte demonstrated an increased number of mitochondria but no change in shape, size, or structure as the pig developed. An increase in a number of cytoplasmic components (Golgi apparatus and endoplasmic reticulum) and a decrease in glycogen were also observed. The functional changes in mitochondria seem to occur within a short period of time (6–12 hr postpartum).

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      Author and article information

      Affiliations
      From the Department of Pharmacology, Shell Development Company, Modesto, California 95352; and the Veterans Administration Hospital and Pediatrics Department, University of California at San Francisco, San Francisco, California 94122
      Journal
      J Cell Biol
      The Journal of Cell Biology
      The Rockefeller University Press
      0021-9525
      1540-8140
      1 May 1972
      : 53
      : 2
      : 335-347
      2108723
      5025105
      Copyright © 1972 by The Rockefeller University Press
      Categories
      Article

      Cell biology

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