7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Distribution of nitric oxide synthase-immunoreactive neurons in fetal rat brains at embryonic day 15 and day 19

      , , , ,
      Journal of Chemical Neuroanatomy
      Elsevier BV

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Although nitric oxide (NO) is hypothesized to play a role in the modelling of neuronal connections in the developing brain, no precise histological information has been reported on nitric oxide synthase immunoreactive (NOS-IR) structures in the embryonic brain. Thus, we examined the distribution of NOS-IR structures in the rat brain at embryonic day 15 (E15) and day 19 (E19), as a stage of early embryonic neurogenesis and active synaptogenesis, respectively. In the brain at E15, a few NOS-IR cell bodies were observed in the diencephalon near the 3rd ventricle and in the pons. By E19, the number of NOS-IR cells was greatly increased. Many NOS-IR cells were distributed throughout the forebrain and the medulla oblongata. NOS-IR cells of the neostriatum were located in its ventrolateral two-thirds. NOS-IR cells in the hypothalamus were distributed densely in the medial part while sparsely in the latero-ventral part, suggesting medio-lateroventral directions of NOS development. In the lower brainstem, on the other hand, NOS-IR cells were distributed in a similar pattern to that reported in adult rat, indicating earlier development of synaptic refinement in this area. The number of NOS-IR cells in the cerebral cortex and the cerebellum was very few.

          Related collections

          Author and article information

          Journal
          Journal of Chemical Neuroanatomy
          Journal of Chemical Neuroanatomy
          Elsevier BV
          08910618
          June 1996
          June 1996
          : 10
          : 3-4
          : 273-278
          Article
          10.1016/0891-0618(96)00141-X
          8811417
          9c83b8ca-c6c3-493c-bfa4-9eb89e79649a
          © 1996

          https://www.elsevier.com/tdm/userlicense/1.0/

          History

          Comments

          Comment on this article