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      Effects of Ageing on Endocrine and Neuroendocrine Rhythms in Humans

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          Abstract

          Biological rhythms in blood variables are now fairly well documented in young healthy adults whereas reports in elderly subjects are few for obvious reasons including the difficulty of setting up a group of elderly subjects comparable in age and social background and moreover free of major liver, heart, kidney, bone or any other degenerative disease and consequently not requiring medication. We have observed that the parameters characteristic of the biological rhythm may be modified with ageing. However, the modifications are different from one function or variable to the next. Differences in acrophases, mesors and amplitudes could be demonstrated. For instance the acrophase may be phase-advanced in the elderly for plasma cortisol, DHEA-S, 18-OHDOC, the amplitude may be modified for testosterone, 18-OHDOC, proteins, melatonin, gonadotrophins. The administration as a function of time of drugs or agents used as a diagnostic tool made it possible to ascertain the importance of the time structure in this field. Both validity and interpretation of such administration depend upon the timing of the agent administration in the 24-hour scale. Therefore, the temporal organization of the subjects undergoing such treatments should be taken into account. In the near future this kind of investigation on various biological variables may lead to an improvement of the desired drug effects in elderly patients.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-6124-2
          978-3-318-01661-1
          1663-2818
          1663-2826
          1995
          1995
          05 December 2008
          : 43
          : 1-3
          : 12-19
          Affiliations
          Service de Biochimie Médicale, Faculté de Médecine Pitié-Salpêtrière, Paris, France
          Article
          184231 Horm Res 1995;43:12–19
          10.1159/000184231
          7721256
          © 1995 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Endocrine Functions and Ageing

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