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      GluT4: A central player in hippocampal memory and brain insulin resistance

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      Experimental Neurology
      Elsevier BV

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          Abstract

          Insulin is now well-established as playing multiple roles within the brain, and specifically as regulating hippocampal cognitive processes and metabolism. Impairments to insulin signaling, such as those seen in type 2 diabetes and Alzheimer’s disease, are associated with brain hypometabolism and cognitive impairment but the mechanisms of insulin’s central effects are not determined. Several lines of research converge to suggest that the insulin - responsive glucose transporter GluT4 plays a central role in hippocampal memory processes, and that reduced activation of this transporter may underpin the cognitive impairments seen as a consequence of insulin resistance.

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          Author and article information

          Journal
          Experimental Neurology
          Experimental Neurology
          Elsevier BV
          00144886
          October 2019
          October 2019
          : 113076
          Article
          10.1016/j.expneurol.2019.113076
          6936336
          31614121
          9cc352bb-9aa5-4a6d-805a-f751a9a44487
          © 2019

          https://www.elsevier.com/tdm/userlicense/1.0/

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