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      Thrombo-hemorrhagic deaths in acute promyelocytic leukemia.

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          Abstract

          Acute promyelocytic leukemia (APL) has become the most curable form of acute myeloid leukemia after the advent of all-trans retinoic acid (ATRA). However, early deaths (ED) mostly due to the disease-associated coagulopathy remain the major cause of treatment failure. In particular, hemorrhagic events account for 40-65% of ED and several prognostic factors have been identified for such hemorrhagic deaths, including poor performance status, high white blood cell (WBC) count and coagulopathy. Occurrence of thrombosis during treatment with ATRA may be associated with differentiation syndrome (DS) or represent an isolated event. Some prognostic factors have been reported to be associated with thrombosis, including increased WBC or aberrant immunophenotype of leukemic promyelocytes. Aim of this review is to report the incidence, severity, possible pathogenesis and clinical manifestations of thrombo-haemorrhagic deaths in APL.

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          Author and article information

          Journal
          Thromb. Res.
          Thrombosis research
          Elsevier BV
          1879-2472
          0049-3848
          May 2014
          : 133 Suppl 2
          Affiliations
          [1 ] Department of Hematology, Sapienza University, Rome, Italy.
          [2 ] Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy; Laboratory of Neuro-Oncohematology, Santa Lucia Foundation, Rome, Italy. Electronic address: Francesco.lo.coco@uniroma2.it.
          Article
          S0049-3848(14)50019-9
          10.1016/S0049-3848(14)50019-9
          24862130

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