Whether intensive control of glucose reduces macrovascular events and all-cause mortality
in individuals with type 2 diabetes mellitus is unclear. We undertook a meta-analysis
of randomised controlled trials to determine whether intensive treatment is beneficial.
We selected five prospective randomised controlled trials of 33 040 participants to
assess the effect of an intensive glucose-lowering regimen on death and cardiovascular
outcomes compared with a standard regimen. We gathered information about events of
non-fatal myocardial infarction, coronary heart disease (fatal and non-fatal myocardial
infarction), stroke, and all-cause mortality, and did a random-effects meta-analysis
to obtain summary effect estimates for the clinical outcomes with use of odds ratios
calculated from the raw data of every trial. Statistical heterogeneity across trials
was assessed with the chi(2) and I(2) statistics.
The five trials provided information on 1497 events of non-fatal myocardial infarction,
2318 of coronary heart disease, 1127 of stroke, and 2892 of all-cause mortality during
about 163 000 person-years of follow-up. The mean haemoglobin A(1c) concentration
(HbA(1c)) was 0.9% lower for participants given intensive treatment than for those
given standard treatment. Intensive glycaemic control resulted in a 17% reduction
in events of non-fatal myocardial infarction (odds ratio 0.83, 95% CI 0.75-0.93),
and a 15% reduction in events of coronary heart disease (0.85, 0.77-0.93). Intensive
glycaemic control had no significant effect on events of stroke (0.93, 0.81-1.06)
or all-cause mortality (1.02, 0.87-1.19).
Overall, intensive compared with standard glycaemic control significantly reduces
coronary events without an increased risk of death. However, the optimum mechanism,
speed, and extent of HbA(1c) reduction might be different in differing populations.
None.