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      Bupranolol, A β 1- and β 2-Blocker, Causes Constriction of the Pupil in Men

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          Abstract

          Two out of three normal eyes tested with frequent instillation of 30 µl of drops of 0.5% bupranolol, a β<sub>1</sub> + β<sub>2</sub> blocking drug with some intrinsic sympathomimetic and local anesthetic activity, showed a miotic effect of the order of a 25% reduction of pupil area, as estimated by an open-loop iris-videorecorder. A slight contralateral effect was also observed. Blocking by the drug of tonic inhibitory β-adrenergic activity on the sphincter muscle of the pupil is postulated.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1986
          1986
          04 December 2009
          : 18
          : 1
          : 11-14
          Affiliations
          aDepartment of Ophthalmology, Yamanashi Medical College, Tamaho, Yamanashi, Japan; bDepartment of Ophthalmology, Ina Central Hospital, Ina, Nagano, Japan
          Article
          265407 Ophthalmic Res 1986;18:11–14
          10.1159/000265407
          3951800
          9ccc2bd7-ad51-4721-832b-9f16dd53d5f3
          © 1986 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 28 January 1985
          : 28 March 1985
          Page count
          Pages: 4
          Categories
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Bupranolol,β1 and β2-blocker,Open-loop iris-videorecorder,Miosis

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