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      Bupranolol, A β 1- and β 2-Blocker, Causes Constriction of the Pupil in Men

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          Two out of three normal eyes tested with frequent instillation of 30 µl of drops of 0.5% bupranolol, a β<sub>1</sub> + β<sub>2</sub> blocking drug with some intrinsic sympathomimetic and local anesthetic activity, showed a miotic effect of the order of a 25% reduction of pupil area, as estimated by an open-loop iris-videorecorder. A slight contralateral effect was also observed. Blocking by the drug of tonic inhibitory β-adrenergic activity on the sphincter muscle of the pupil is postulated.

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          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          04 December 2009
          : 18
          : 1
          : 11-14
          aDepartment of Ophthalmology, Yamanashi Medical College, Tamaho, Yamanashi, Japan; bDepartment of Ophthalmology, Ina Central Hospital, Ina, Nagano, Japan
          265407 Ophthalmic Res 1986;18:11–14
          © 1986 S. Karger AG, Basel

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