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      A review of impaired visual processing and the daily visual world in patients with schizophrenia

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          ABSTRACT

          Several studies have investigated perceptual processes in patients with schizophrenia. Research confirms that visual impairments are one of the most important features of schizophrenia. Many studies, using behavioral and psychological experiments, confirm that visual impairments can be used to determine illness severity, state, and best treatments. Herein, we review recent research pertaining to visual function in patients with schizophrenia and highlight the relationship between laboratory findings and subjective, real-life reports from patients themselves. The purpose of this review is to 1) describe visual impairments that manifest in patients with schizophrenia, 2) examine the relationship between visual dysfunction, assessed by laboratory tests, and the experiences of patients themselves, and 3) describe real-life experiences related to visual function in this population. In this review, the impairments of motion and color perception, perceptual organization, and scan paths are summarized, along with the relationship between laboratory findings and patients’ real-world subjective experiences related to visual function.

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          Most cited references55

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          A meta-analysis of cognitive deficits in adults with a diagnosis of schizophrenia.

          This review identified 1275 studies examining cognitive deficits in people with schizophrenia, published between 1990 and 2003. Data from 113 studies (4365 patients and 3429 controls) were combined in a meta-analysis carried out on the five cognitive domains of IQ, memory, language, executive function, and attention. Studies were excluded where they lacked a suitable control group or failed to present complete information. In all five cognitive domains, analysis indicated a consistent trend for patients to perform more poorly than healthy controls, with significant heterogeneity across studies. Sources of heterogeneity were analyzed and a need to ensure more appropriate composition of patient and control groups and to adopt a more refined and methodologically correct, hypothesis-driven approach was identified.
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            Perceptual organization impairment in schizophrenia and associated brain mechanisms: review of research from 2005 to 2010.

            Perceptual organization (PO) refers to the processes by which visual information is structured into coherent patterns such as groups, contours, perceptual wholes, and object representations. Impairments in PO have been demonstrated in schizophrenia since the 1960s and have been linked to several illness-related factors including poor premorbid functioning, poor prognosis, and disorganized symptoms. This literature was last reviewed in 2005. Since then, electrophysiological (electroencephalographic, event-related potential, and magnetoencephalographic) and fMRI studies in both patient and nonpatient samples have clarified brain mechanisms involved in the impairment, and additional behavioral studies in patients and nonpatients have clarified the computational mechanisms. In addition, data now exist on the functional consequences of PO impairments, in terms of secondary difficulties in face processing, selective attention, working memory, and social cognition. Preliminary data on drug effects on PO and on changes in response to treatment suggest that anomalies in PO may furnish a biomarker for the integrity of its associated biological mechanisms. All of this recent evidence allows for a clearer picture of the nature of the impairment and how it relates to broader aspects of brain and behavioral functioning in schizophrenia.
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              The early symptoms of schizophrenia.

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                Author and article information

                Journal
                Nagoya J Med Sci
                Nagoya J Med Sci
                Nagoya Journal of Medical Science
                Nagoya University
                0027-7622
                2186-3326
                August 2018
                : 80
                : 3
                : 317-328
                Affiliations
                [1 ]Department of Physical and Occupational Therapy, Nagoya University, Nagoya, Japan
                [2 ]Brain & Mind Research Center, Nagoya University, Nagoya, Japan
                Author notes

                Corresponding author: Tetsuya Iidaka, MD

                Department of Physical and Occupational Therapy, Nagoya University, Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya Aichi, 461-8673, Japan.

                E-mail: iidaka@met.nagoya-u.ac.jp

                Article
                10.18999/nagjms.80.3.317
                6125648
                30214081
                9cda9cd6-17cb-4ed1-b05f-572af47920fd

                This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit ( http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 15 January 2018
                : 11 April 2018
                Categories
                Invited Review Article

                schizophrenia,visual impairment,motion and color perception,scan path,real life

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