Soluble interleukin-2 receptor alfa predicts renal outcome in IgA nephropathy.

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Abstract

Both systemic and mucosal IgA production are controlled by T lymphocytes and infiltrating T lymphocytes are involved in the progression of interstitial fibrosis in chronic kidney disease (CKD). Since the concentration of soluble interleukin-2 receptor alfa (sIL-2Ra) reflects the degree of T cell activation over time, we studied the impact of interleukin-2 receptor alfa levels on disease progression in patients with biopsy-proven IgA nephropathy (IgAN), a disease in which 20-30% of the patients progress to end-stage renal failure.

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Journal

Journal ID (iso-abbrev): Nephrol Dial Transplant

Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1460-2385

ISSN (Print): 0931-0509

Publication date (Electronic): May 2012

Volume: 27

Issue: 5

Affiliations

[1 ] Nephrology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden. sigrid.lundberg@karolinska.se

Article

Publisher Item ID: gfr554

DOI: 10.1093/ndt/gfr554

PubMed ID: 21940483

SO-VID: 9ce16744-13ce-415d-b2f2-10a73e3f08e4

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