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      Streptozotocin-induced diabetic models in mice and rats.

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          Abstract

          Streptozotocin (STZ) is an antibiotic that can cause pancreatic β-cell destruction, so it is widely used experimentally as an agent capable of inducing insulin-dependent diabetes mellitus (IDDM), also known as type 1 diabetes mellitus (T1DM). This unit describes protocols for the production of insulin deficiency and hyperglycemia in mice and rats, using STZ. These models for diabetes can be employed for assessing the mechanisms of T1DM, screening potential therapies for the treatment of this condition, and evaluation of therapeutic options.

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          Author and article information

          Journal
          Curr Protoc Pharmacol
          Current protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.]
          1934-8290
          1934-8282
          Mar 2008
          : Chapter 5
          Affiliations
          [1 ] Merck Research Laboratories, Rahway, New Jersey, USA.
          Article
          10.1002/0471141755.ph0547s40
          22294227
          9ce4fffe-ee85-4339-8c0d-d9a5fddca1cd
          © 2008 by John Wiley & Sons, Inc.
          History

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