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      Location, location, location: cytokine concentrations are dependent on blood sampling site.

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          Abstract

          Considerable breakthroughs in the field of sepsis have been made using animal models. Sepsis exhibits a wide array of derangements that may be evaluated in the blood, including the release of proinflammatory and anti-inflammatory cytokines. The Shock journal adheres to the ARRIVE guidelines regarding reporting in vivo results to allow reproducibility of data findings. It is generally assumed that blood cytokine concentrations collected from typical sampling sites will be similar, but there are no data validating that this is true. The main purpose of the present study was to determine if the location of blood sampling results in cytokine concentration differences following inflammatory insults.

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          Author and article information

          Journal
          Shock
          Shock (Augusta, Ga.)
          Ovid Technologies (Wolters Kluwer Health)
          1540-0514
          1073-2322
          Oct 2014
          : 42
          : 4
          Affiliations
          [1 ] *Department of Pathology and Laboratory Medicine, Boston University School of Medicine; and †Department of Surgery, Boston University Medical Center, Boston, Massachusetts.
          Article
          NIHMS602474
          10.1097/SHK.0000000000000222
          4167217
          25004061
          9ce713ce-3805-430e-8259-c7fd0b5380f9
          History

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