- Record: found
- Abstract: found
- Article: not found
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang , Prof, MD a , * , Yeming Wang , MD b , e , f , * , Xingwang Li , Prof, MD g , * , Lili Ren , Prof, PhD h , * , Jianping Zhao , Prof, MD j , * , Yi Hu , MD k , * , Li Zhang , Prof, MD a , Guohui Fan , MS b , c , e , Jiuyang Xu , MDc l , Xiaoying Gu , PhD b , c , e , Zhenshun Cheng , Prof, MD m , Ting Yu , MD a , Jiaan Xia , MD a , Yuan Wei , MD a , Wenjuan Wu , Prof, MD a , Xuelei Xie , Prof, MD a , Wen Yin , MD k , Hui Li , MD b , e , f , Min Liu , MD d , Yan Xiao , MS h , Hong Gao , Prof, PhD i , Li Guo , Prof, PhD h , Jungang Xie , Prof, MD j , Guangfa Wang , Prof, MD n , Rongmeng Jiang , Prof, MD g , Zhancheng Gao , Prof, MD o , Qi Jin , PhD h , Jianwei Wang , Prof, PhD h , † , ** , Bin Cao , Prof, MD b , e , f , p , † , *
24 January 2020
Read this article at
Summary
Background
A recent cluster of pneumonia cases in Wuhan, China, was caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV). We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients.
Methods
All patients with suspected 2019-nCoV were admitted to a designated hospital in Wuhan. We prospectively collected and analysed data on patients with laboratory-confirmed 2019-nCoV infection by real-time RT-PCR and next-generation sequencing. Data were obtained with standardised data collection forms shared by WHO and the International Severe Acute Respiratory and Emerging Infection Consortium from electronic medical records. Researchers also directly communicated with patients or their families to ascertain epidemiological and symptom data. Outcomes were also compared between patients who had been admitted to the intensive care unit (ICU) and those who had not.
Findings
By Jan 2, 2020, 41 admitted hospital patients had been identified as having laboratory-confirmed 2019-nCoV infection. Most of the infected patients were men (30 [73%] of 41); less than half had underlying diseases (13 [32%]), including diabetes (eight [20%]), hypertension (six [15%]), and cardiovascular disease (six [15%]). Median age was 49·0 years (IQR 41·0–58·0). 27 (66%) of 41 patients had been exposed to Huanan seafood market. One family cluster was found. Common symptoms at onset of illness were fever (40 [98%] of 41 patients), cough (31 [76%]), and myalgia or fatigue (18 [44%]); less common symptoms were sputum production (11 [28%] of 39), headache (three [8%] of 38), haemoptysis (two [5%] of 39), and diarrhoea (one [3%] of 38). Dyspnoea developed in 22 (55%) of 40 patients (median time from illness onset to dyspnoea 8·0 days [IQR 5·0–13·0]). 26 (63%) of 41 patients had lymphopenia. All 41 patients had pneumonia with abnormal findings on chest CT. Complications included acute respiratory distress syndrome (12 [29%]), RNAaemia (six [15%]), acute cardiac injury (five [12%]) and secondary infection (four [10%]). 13 (32%) patients were admitted to an ICU and six (15%) died. Compared with non-ICU patients, ICU patients had higher plasma levels of IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNFα.
Interpretation
The 2019-nCoV infection caused clusters of severe respiratory illness similar to severe acute respiratory syndrome coronavirus and was associated with ICU admission and high mortality. Major gaps in our knowledge of the origin, epidemiology, duration of human transmission, and clinical spectrum of disease need fulfilment by future studies.
Related collections
Most cited references 4
- Record: found
- Abstract: not found
- Article: not found
Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group
- Record: found
- Abstract: found
- Article: not found
Corticosteroids as adjunctive therapy in the treatment of influenza.
- Record: found
- Abstract: found
- Article: not found
Bats as animal reservoirs for the SARS coronavirus: Hypothesis proved after 10 years of virus hunting
Author and article information
Contributors
Journal
Affiliations
Author notes
Article
S0140-6736(20)30183-5Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.