15
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Peptide-Drug Conjugates and Their Targets in Advanced Cancer Therapies

      review-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Cancer became recently the leading cause of death in industrialized countries. Even though standard treatments achieve significant effects in growth inhibition and tumor elimination, they cause severe side effects as most of the applied drugs exhibit only minor selectivity for the malignant tissue. Hence, specific addressing of tumor cells without affecting healthy tissue is currently a major desire in cancer therapy. Cell surface receptors, which bind peptides are frequently overexpressed on cancer cells and can therefore be considered as promising targets for selective tumor therapy. In this review, the benefits of peptides as tumor homing agents are presented and an overview of the most commonly addressed peptide receptors is given. A special focus was set on the bombesin receptor family and the neuropeptide Y receptor family. In the second part, the specific requirements of peptide-drug conjugates (PDC) and intelligent linker structures as an essential component of PDC are outlined. Furthermore, different drug cargos are presented including classical and recent toxic agents as well as radionuclides for diagnostic and therapeutic approaches. In the last part, boron neutron capture therapy as advanced targeted cancer therapy is introduced and past and recent developments are reviewed.

          Related collections

          Most cited references242

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Acidic extracellular microenvironment and cancer

          Acidic extracellular pH is a major feature of tumor tissue, extracellular acidification being primarily considered to be due to lactate secretion from anaerobic glycolysis. Clinicopathological evidence shows that transporters and pumps contribute to H+ secretion, such as the Na+/H+ exchanger, the H+-lactate co-transporter, monocarboxylate transporters, and the proton pump (H+-ATPase); these may also be associated with tumor metastasis. An acidic extracellular pH not only activates secreted lysosomal enzymes that have an optimal pH in the acidic range, but induces the expression of certain genes of pro-metastatic factors through an intracellular signaling cascade that is different from hypoxia. In addition to lactate, CO2 from the pentose phosphate pathway is an alternative source of acidity, showing that hypoxia and extracellular acidity are, while being independent from each other, deeply associated with the cellular microenvironment. In this article, the importance of an acidic extracellular pH as a microenvironmental factor participating in tumor progression is reviewed.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Paul Ehrlich's magic bullet concept: 100 years of progress.

            Exceptional advances in molecular biology and genetic research have expedited cancer drug development tremendously. The declared paradigm is the development of 'personalized and tailored drugs' that precisely target the specific molecular defects of a cancer patient. It is therefore appropriate to revisit the intellectual foundations of the development of such agents, as many have shown great clinical success. One hundred years ago, Paul Ehrlich, the founder of chemotherapy, received the Nobel Prize for Physiology or Medicine. His postulate of creating 'magic bullets' for use in the fight against human diseases inspired generations of scientists to devise powerful molecular cancer therapeutics.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              Glutathione metabolism in cancer progression and treatment resistance

              Bansal and Simon discuss strategies to block glutathione synthesis and utilization pathways to inhibit tumor propagation and treatment resistance.
                Bookmark

                Author and article information

                Contributors
                Journal
                Front Chem
                Front Chem
                Front. Chem.
                Frontiers in Chemistry
                Frontiers Media S.A.
                2296-2646
                07 July 2020
                2020
                : 8
                : 571
                Affiliations
                Faculty of Life Sciences, Institute of Biochemistry, Leipzig University , Leipzig, Germany
                Author notes

                Edited by: Jennifer L. Schaefer, University of Notre Dame, United States

                Reviewed by: Rakesh Kumar Tiwari, Chapman University, United States; Kyeongsoon Park, Chung-Ang University, South Korea; Piotr A. Mroz, Indiana University, United States

                *Correspondence: Annette G. Beck-Sickinger abeck-sickinger@ 123456uni-leipzig.de

                This article was submitted to Medicinal and Pharmaceutical Chemistry, a section of the journal Frontiers in Chemistry

                Article
                10.3389/fchem.2020.00571
                7359416
                32733853
                9cf63246-b896-4f39-a881-6eb726c043e0
                Copyright © 2020 Hoppenz, Els-Heindl and Beck-Sickinger.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 24 March 2020
                : 03 June 2020
                Page count
                Figures: 11, Tables: 2, Equations: 0, References: 288, Pages: 24, Words: 18631
                Categories
                Chemistry
                Review

                peptide,gpcr,cancer,peptide-drug conjugate,boron neutron capture therapy

                Comments

                Comment on this article