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      • Record: found
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      An amelanotic choroidal melanoma arising in a young man with tattoo-associated sarcoidosis

      case-report
      Author(s): , BS a , ∗∗ , , BS, COMT b , , MD b
      Publication date (Electronic):
      Journal: American Journal of Ophthalmology Case Reports
      Publisher: Elsevier
      Keywords: Uveal melanoma, Eye, Tumor, Sarcoidosis

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          Abstract

          Purpose

          To describe a patient with an amelanotic choroidal melanoma, originally misdiagnosed as a choroidal granuloma, following his systemic diagnosis of tattoo-associated sarcoidosis.

          Observations

          The amelanotic choroidal tumor, suspected to be a granuloma, failed initial steroid treatment. Full-thickness chorioretinal biopsy demonstrated histologic presence of uveal melanoma and tumor genetics via GEP analysis demonstrated a PRAME negative, Class 1A lesion. The amelanotic choroidal melanoma was treated successfully with I-125 plaque brachytherapy.

          Conclusion and importance

          Despite a systemic diagnosis which predisposes a patient to uveal granuloma, amelanotic choroidal melanomas can still occur and should be considered. The association of uveal melanoma and sarcoidosis remains rare and of unclear significance.

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          Most cited references28

          • Record: found
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          PRAME as an Independent Biomarker for Metastasis in Uveal Melanoma.

          M. Field, C. Decatur, S Kurtenbach … (2016)
          Uveal melanoma (UM) can be classified by gene expression profiling (GEP) into Class 1 (low metastatic risk) and Class 2 (high metastatic risk), the latter being strongly associated with mutational inactivation of the tumor suppressor BAP1. Nevertheless, a small percentage of Class 1 tumors give rise to metastatic disease. The purpose of this study was to identify biomarkers of metastasis in Class 1 tumors.
          Article 0 comments Cited 83 times – based on 0 reviews     Review now
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            Sarcoidosis and malignancy.

            Philip R. Cohen, Razelle Kurzrock (2015)
            Malignancy in patients with sarcoidosis occurs in 3 settings. The first setting relates to patients with hematologic malignancies. It includes the sarcoidosis-lymphoma syndrome, which refers to the development of lymphoma at least 1 to 2 years after the diagnosis of sarcoidosis. It also includes patients with sarcoidosis who develop other hematologic malignancies. In addition, this subset of individuals includes patients with cancer and hematologic malignancies who subsequently develop sarcoidosis. The second setting consists of patients with sarcoidosis who develop solid tumors and oncologic patients in whom sarcoidosis subsequently appears; in addition to melanoma and nonmelanoma skin cancer, the neoplasms most commonly associated involve the cervix, liver, lung, testicles, and uterus. The third setting of malignancy-related sarcoidosis occurs when sarcoidosis presents as a paraneoplastic syndrome for the associated cancer, specifically when the discovery of cancer is concurrent with or within 1 year of the diagnosis of sarcoidosis or vis-a-vis. Antineoplastic treatment of either the hematologic malignancy or the solid tumor has also been observed to either induce the initial onset or flare the activity of sarcoidosis. Malignancy can also be associated with the occurrence of sarcoid reactions that typically are restricted to the regional lymph nodes or the visceral organ of tumor origin; rarely, the sarcoid reaction can also be observed in the skin or is only limited to the skin.
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              Sarcoidosis and its ophthalmic manifestations.

              Gordon Klintworth, Megan H. Shaw, C F Sydnor … (1978)
              Of 532 cases of sarcoidosis in the southeastern United States, ocular manifestations were a prominent feature of the disease in 202 (38%) of the patients. Approximately one fifth of them sought medical attention because of ocular complaints. This was the second most frequent clinical manifestation, exceeded only by pulmonary symptoms. When ocular segment structures were affected, the anterior segment was involved in 171 (84.7%) of cases. Chronic granulomatous uveitis was the most common abnormality in 106 cases (52.5%). Posterior segment disease occurred in 51 (25.3%) of cases, usually in the form of chorioretinitis or preiphlebitis; it was sometimes the sole manifestation of ocular sarcoidosis, but usually accompanied abnormalities in the anterior part of the eye. The incidence of central nervous system sarcoidosis was increased when posterior segment involvement was observed. Orbital and adnexal structures, primarily lacrimal gland, were affected in 53 (27.7%) of cases.
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                Author and article information

                Contributors
                Sean T. Berkowitz
                Journal
                Journal ID (nlm-ta): Am J Ophthalmol Case Rep
                Journal ID (iso-abbrev): Am J Ophthalmol Case Rep
                Title: American Journal of Ophthalmology Case Reports
                Publisher: Elsevier
                ISSN (Print): 2451-9936
                ISSN (Electronic): 2451-9936
                Publication date PMC-release: 07 March 2020
                Publication date Collection: June 2020
                Publication date (Electronic): 07 March 2020
                Volume: 18
                Electronic Location Identifier: 100655
                Affiliations
                [a ]Vanderbilt University School of Medicine, USA
                [b ]Tennessee Retina, PC, Nashville, TN, USA
                Author notes
                [∗ ]Corresponding author. 2209 Garland Avenue, Nashville, TN 37240-0002, USA. sean.t.berkowitz@ 123456vanderbilt.edu
                Article
                Publisher ID: S2451-9936(20)30036-0 Publisher ID: 100655
                DOI: 10.1016/j.ajoc.2020.100655
                PMC ID: 7082514
                SO-VID: 9cf82532-2ac5-4a2d-bfe8-949745ade22c
                Copyright © © 2020 The Authors
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 18 November 2019
                Date accepted : 4 March 2020
                Categories
                Subject: Case Report

                Keywords: uveal melanoma,eye,tumor,sarcoidosis
                Data availability:
                Keywords: uveal melanoma, eye, tumor, sarcoidosis

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